{"id":"W2547344275","doi":"10.1158/2326-6066.imm2016-b058","title":"Abstract B058: Development of AVID200, a novel and highly potent TGF-beta neutralizing immunotherapy","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; National Research Council Canada","funders":"","keywords":"Cancer research; Immunotherapy; Tumor microenvironment; T cell; Ex vivo; Cancer immunotherapy; CD8; In vivo; Immune system; Medicine; Chemistry; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012824,0.0001962692,0.0004513408,0.0003953487,0.0002619534,0.00001797746,0.0003046944,0.0001893847,0.0006107073],"category_scores_gemma":[0.00006401337,0.0001231446,0.00008728442,0.000307966,0.001076078,0.00009583426,0.0002635671,0.0005585897,0.00007351605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263397,"about_ca_system_score_gemma":0.0008455209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006377643,"about_ca_topic_score_gemma":0.00005657149,"domain_scores_codex":[0.9975104,0.00009188811,0.0004806866,0.0004298281,0.0006286892,0.0008585014],"domain_scores_gemma":[0.9984391,0.0003951862,0.00008180508,0.0003851606,0.0005305327,0.0001681826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001579593,0.0001778117,0.01274314,0.00013731,0.0003914831,0.00002483006,0.0005523511,1.488013e-7,0.7872367,0.0008402587,0.0003347314,0.1959817],"study_design_scores_gemma":[0.003112079,0.0004168116,0.577926,0.000613839,0.00001065364,0.00007211955,0.0002004573,0.000003369128,0.3306279,0.0001270801,0.08670303,0.000186699],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713014,0.01678527,0.00005726588,0.009439343,0.0001363876,0.0004313266,0.00003193616,0.00002518249,0.001791932],"genre_scores_gemma":[0.9831681,0.009473284,0.0008634377,0.0001203395,0.0001153047,0.0001302821,0.000008369743,0.00003523691,0.006085643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5651828,"threshold_uncertainty_score":0.6686816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231973994842351,"score_gpt":0.4122587525665377,"score_spread":0.2890613530823026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}