{"id":"W2547344275","doi":"10.1158/2326-6066.imm2016-b058","title":"Abstract B058: Development of AVID200, a novel and highly potent TGF-beta neutralizing immunotherapy","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; National Research Council Canada","funders":"","keywords":"Cancer research; Immunotherapy; Tumor microenvironment; T cell; Ex vivo; Cancer immunotherapy; CD8; In vivo; Immune system; Medicine; Chemistry; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886485,0.000445973,0.0001737143,0.000251554,0.00009647942,0.0002698106,0.0004624259,0.0004969875,0.001172971],"category_scores_gemma":[0.00007191867,0.0001140643,0.0002002642,0.0001058636,0.0001187571,0.0002083568,0.0001681243,0.0005794126,0.0004242292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003094958,"about_ca_system_score_gemma":0.0002738791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005671678,"about_ca_topic_score_gemma":0.000559672,"domain_scores_codex":[0.9999161,0.000009238546,0.000004467541,0.00001728253,0.0000338059,0.00001914585],"domain_scores_gemma":[0.9999653,0.000003133705,0.000008464822,0.000002571798,0.000006598309,0.00001394141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002134878,0.0003079034,0.0001378652,0.00006857887,0.00001050632,0.00007878669,0.00001680533,0.0004427288,0.9798078,0.0003509259,0.0003582461,0.01820635],"study_design_scores_gemma":[0.0002965695,0.004591328,0.001618178,0.00001789867,0.00003917524,0.001080878,0.000009345593,0.004683404,0.9746027,0.0001093771,0.01293976,0.00001134129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570522,0.006661364,0.0285208,0.0003795568,0.0001052167,0.0003405366,0.0005729055,0.0003115589,0.006055837],"genre_scores_gemma":[0.9731222,0.002393245,0.01708278,0.0002114358,0.00004675266,0.0001638093,0.001338769,0.00002609802,0.005615024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172971,"threshold_uncertainty_score":0.003923953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231973994842351,"score_gpt":0.4122587525665377,"score_spread":0.2890613530823026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}