{"id":"W2547437312","doi":"","title":"SGK1 (glucose transport), dishevelled2 (wnt signaling), LC3/p62 (autophagy) and p53 (apoptosis) proteins are unaltered in Lafora disease.","year":2016,"lang":"en","type":"article","venue":"PubMed","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs; Hospital for Sick Children","funders":"","keywords":"Lafora disease; Autophagy; Glycogen synthase; Glycogen; Neurodegeneration; Biology; GSK-3; Wnt signaling pathway; Cell biology; Endocrinology; Glucose transporter; GSK3B; Internal medicine; Kinase; Signal transduction; Apoptosis; Phosphorylation; Biochemistry; Phosphatase; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002723191,0.0003419561,0.0005326134,0.0002027925,0.00008163606,0.00002965791,0.0001455893,0.0001169503,0.0001623772],"category_scores_gemma":[0.0002050175,0.0002355152,0.0002092136,0.0002673327,0.000132408,0.0002069196,0.00004748179,0.0001565328,0.00002108924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386253,"about_ca_system_score_gemma":0.0001158813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007282083,"about_ca_topic_score_gemma":0.00003287362,"domain_scores_codex":[0.9975968,0.0000600229,0.0004850634,0.0006443418,0.0004287679,0.0007850059],"domain_scores_gemma":[0.9982103,0.00005982102,0.0001530391,0.0004327667,0.00009372472,0.001050352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01050373,0.004100278,0.5414339,0.002326553,0.0007114667,0.0273156,0.0008245448,0.00001452689,0.01716358,0.0008313123,0.001451361,0.3933232],"study_design_scores_gemma":[0.005908764,0.00008304782,0.974677,0.0003784928,0.0003234522,0.00006411449,0.00007721922,0.00001235552,0.01105494,0.0003609083,0.006615981,0.0004437406],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915183,0.002497388,0.0001075513,0.002511111,0.0001754725,0.002643618,0.0002157924,0.000127635,0.0002031229],"genre_scores_gemma":[0.9945491,0.0003307257,0.00007714657,0.0006054227,0.0002243574,0.002709238,0.00004857904,0.00006073719,0.001394698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4332431,"threshold_uncertainty_score":0.960403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167051672981757,"score_gpt":0.2117219226466563,"score_spread":0.1950167553484806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}