{"id":"W2547555153","doi":"10.1021/acs.molpharmaceut.6b00711","title":"Single and Combinational siRNA Therapy of Cancer Cells: Probing Changes in Targeted and Nontargeted Mediators after siRNA Treatment","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Cancer Society; Natural Sciences and Engineering Research Council of Canada; Chapman University","keywords":"Gene silencing; Small interfering RNA; RNA interference; Biology; Cell biology; Cell; Cancer cell; Cancer research; Population; Cancer; Messenger RNA; RNA; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000292838,0.0003424115,0.0006249561,0.0003256339,0.0001807049,0.0004181546,0.0002200207,0.0004697158,0.000940446],"category_scores_gemma":[0.0001748885,0.0001923423,0.0003151877,0.0002636749,0.0002946856,0.0003265933,0.0001726567,0.0005923561,0.0003564128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003094507,"about_ca_system_score_gemma":0.0001991157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004335988,"about_ca_topic_score_gemma":0.0008635235,"domain_scores_codex":[0.9996871,0.00004727973,0.00002085462,0.00006943515,0.00011438,0.00006093923],"domain_scores_gemma":[0.9998697,0.00004161237,0.00002206102,0.00002046654,0.00002365186,0.00002260489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009289169,0.00003571134,0.0001027083,0.00002648941,0.000005291187,0.00001617561,0.0000153416,0.00005067726,0.9981701,0.00002781714,0.00001373675,0.001442933],"study_design_scores_gemma":[0.000006534567,0.0004438144,0.001919743,0.000001459896,0.00001591181,0.00005397927,0.0000156699,0.0007353089,0.9963348,0.00001806435,0.0004514708,0.000003273901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878901,0.003077501,0.006542887,0.0000652974,0.00005399676,0.00008947255,0.0001516323,0.00006848409,0.002060665],"genre_scores_gemma":[0.9916505,0.001208269,0.004118695,0.00004721792,0.00001884759,0.0001177841,0.0001340107,0.00002358995,0.002681149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000940446,"threshold_uncertainty_score":0.003146112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850837830473008,"score_gpt":0.2831037174316209,"score_spread":0.2645953391268909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}