{"id":"W2547555153","doi":"10.1021/acs.molpharmaceut.6b00711","title":"Single and Combinational siRNA Therapy of Cancer Cells: Probing Changes in Targeted and Nontargeted Mediators after siRNA Treatment","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Cancer Society; Natural Sciences and Engineering Research Council of Canada; Chapman University","keywords":"Gene silencing; Small interfering RNA; RNA interference; Biology; Cell biology; Cell; Cancer cell; Cancer research; Population; Cancer; Messenger RNA; RNA; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006220536,0.0001561841,0.0001420826,0.00006774918,0.00001879713,0.000009681888,0.00006223596,0.00008693375,0.00002859505],"category_scores_gemma":[0.000006974213,0.000115735,0.00003325513,0.00005611888,0.00008879144,0.00000541849,0.00004838267,0.00003547276,6.212061e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000030637,"about_ca_system_score_gemma":0.00003952165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004907388,"about_ca_topic_score_gemma":0.0001905865,"domain_scores_codex":[0.9992708,0.00005037083,0.0001495292,0.0002506827,0.00009668722,0.0001819392],"domain_scores_gemma":[0.9996814,0.00001224817,0.00006553366,0.0001097647,0.00006452812,0.00006659615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001323938,0.0001204326,0.007858218,0.00001162396,0.00008579477,0.0000111016,0.0001936167,0.000006617323,0.9554396,0.000002729261,0.00001329443,0.03612462],"study_design_scores_gemma":[0.00185916,0.0004031277,0.002435407,0.00003268284,0.00001814175,0.000002427268,0.00002393483,0.00005945131,0.989961,0.00002023457,0.005032775,0.0001516399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985957,0.01326536,0.00006346804,0.0003256169,0.00008932005,0.0002136344,0.00005014129,0.000004756193,0.00003070796],"genre_scores_gemma":[0.98935,0.0100385,0.00009856407,0.0003067212,0.0000342263,0.00006388923,0.00001785035,0.00001800018,0.00007223511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03597298,"threshold_uncertainty_score":0.4719537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850837830473008,"score_gpt":0.2831037174316209,"score_spread":0.2645953391268909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}