{"id":"W2547560195","doi":"10.1212/wnl.86.16_supplement.s43.007","title":"Can Pyrimethamine Lower CSF SOD1 Levels in Familial ALS? Results from a Multicenter Phase Ib Trial (S43.007)","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pyrimethamine; SOD1; Medicine; Phase (matter); Internal medicine; Pediatrics; Immunology; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002068628,0.0007552562,0.001677358,0.0001718012,0.0002914331,0.0007122556,0.0004914473,0.001517153,0.002355441],"category_scores_gemma":[0.001015038,0.000262527,0.001272416,0.0002225489,0.0004301996,0.0007109023,0.0001948561,0.001380451,0.0004834933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004718607,"about_ca_system_score_gemma":0.000577309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004561589,"about_ca_topic_score_gemma":0.00108193,"domain_scores_codex":[0.9995162,0.000276163,0.00003862205,0.00006445279,0.00003459892,0.00006992142],"domain_scores_gemma":[0.9994611,0.0001187836,0.0001480125,0.00004033037,0.00005723695,0.0001746357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8381249,0.009232861,0.007146843,0.001579765,0.004256472,0.0001891101,0.0002300571,0.0009781217,0.02097769,0.000286728,0.004402255,0.1125953],"study_design_scores_gemma":[0.705723,0.2616259,0.02354507,0.0002169795,0.001848816,0.0002835219,0.0000790639,0.0006934952,0.001690844,0.0003268107,0.003932147,0.00003430021],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842093,0.01072405,0.0003386694,0.001356869,0.0001712849,0.0007992187,0.0007917666,0.00006827834,0.00154047],"genre_scores_gemma":[0.9914767,0.003453414,0.0006907833,0.001325847,0.0001870708,0.0008884975,0.0009747298,0.00001390055,0.0009890933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355441,"threshold_uncertainty_score":0.01094007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06705375137670604,"score_gpt":0.352503964458638,"score_spread":0.2854502130819319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}