{"id":"W2547905121","doi":"10.1371/journal.pone.0165951","title":"E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Réseau de Recherche en Santé Buccodentaire et Osseuse; F. Hoffmann-La Roche","keywords":"Chromatin immunoprecipitation; Gene knockdown; E2F1; Transcription factor; E2F; Promoter; Luciferase; Biology; Molecular biology; Transcription (linguistics); Transcriptional regulation; Gene expression; Gene; Transfection; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640834,0.0003206909,0.0002866851,0.0003073812,0.000154958,0.0002958203,0.000133658,0.0003050492,0.001083071],"category_scores_gemma":[0.0001699336,0.0001679066,0.000241297,0.0001928657,0.0002375818,0.0001579603,0.0002173626,0.0002776988,0.0004291931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264225,"about_ca_system_score_gemma":0.0001658149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001257062,"about_ca_topic_score_gemma":0.0009736973,"domain_scores_codex":[0.9997689,0.0000278376,0.00001535205,0.00005606494,0.00006757816,0.00006423409],"domain_scores_gemma":[0.9998978,0.0000172683,0.00002535197,0.00001002596,0.00001599902,0.00003351346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001804301,0.00002123985,0.001379512,0.00003343786,0.00000611374,0.0001001925,0.00002239739,0.00005900622,0.996866,0.00004297279,0.00004384397,0.001244874],"study_design_scores_gemma":[0.00005302961,0.0004541154,0.1042655,0.00001101372,0.0000258567,0.00122236,0.0001483822,0.002337848,0.8864577,0.00008425242,0.004927034,0.00001282027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991998,0.004318887,0.00240913,0.0000596651,0.00001460729,0.0000175598,0.0005010551,0.00004341942,0.0006376129],"genre_scores_gemma":[0.9927101,0.001007101,0.001832115,0.00005670333,0.000008987844,0.00004227144,0.0009757511,0.00001414031,0.003352873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257062,"threshold_uncertainty_score":0.003623247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390525688691164,"score_gpt":0.1900877445349153,"score_spread":0.1761824876480037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}