{"id":"W2547905121","doi":"10.1371/journal.pone.0165951","title":"E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Réseau de Recherche en Santé Buccodentaire et Osseuse; F. Hoffmann-La Roche","keywords":"Chromatin immunoprecipitation; Gene knockdown; E2F1; Transcription factor; E2F; Promoter; Luciferase; Biology; Molecular biology; Transcription (linguistics); Transcriptional regulation; Gene expression; Gene; Transfection; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040607,0.0001119494,0.0001354479,0.00003680647,0.00003920887,0.00001583953,0.00005827721,0.0001038023,0.0000153541],"category_scores_gemma":[0.0001182681,0.00008678063,0.00001762897,0.00003273538,0.0000893461,0.000007897946,0.0001095506,0.00004613514,0.00000796616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006393991,"about_ca_system_score_gemma":0.00001742491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002845714,"about_ca_topic_score_gemma":0.00001822382,"domain_scores_codex":[0.9992085,0.00004275229,0.0001424702,0.000288337,0.0001109544,0.0002070216],"domain_scores_gemma":[0.9996143,0.00002289867,0.00003596337,0.0002123339,0.00003132901,0.00008320449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005676185,0.0001051535,0.007284199,0.00003832941,0.00001465092,0.000008677396,0.00004186923,5.365681e-7,0.9915955,0.00001273056,0.00002271824,0.0008188552],"study_design_scores_gemma":[0.001073434,0.0002172541,0.004343293,0.000353536,0.00001589427,0.000008907966,0.00001161528,0.00001289432,0.9935108,0.0001432058,0.0001656443,0.0001434823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974337,0.002027779,0.00008655145,0.0001800317,0.00001494832,0.0001302797,0.000008684588,0.00001245005,0.0001056392],"genre_scores_gemma":[0.9979728,0.0003932416,0.001131385,0.00007452062,0.00008014675,0.0000205694,0.000008647095,0.00001734423,0.000301389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002940906,"threshold_uncertainty_score":0.3538812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390525688691164,"score_gpt":0.1900877445349153,"score_spread":0.1761824876480037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}