{"id":"W2548002637","doi":"10.1016/j.vaccine.2016.10.061","title":"In vivo screen of genetically conserved Streptococcus pneumoniae proteins for protective immunogenicity","year":2016,"lang":"en","type":"article","venue":"Vaccine","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Biology; Immunogenicity; Serotype; Streptococcus pneumoniae; Antigen; Virology; Microbiology; Pneumococcal infections; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004199661,0.0006404598,0.0003684358,0.0002786336,0.0002262887,0.0002766947,0.0003255057,0.0005001425,0.001753041],"category_scores_gemma":[0.0002807252,0.0002295297,0.0004137265,0.0001983025,0.0002900483,0.0001979468,0.0001827813,0.00116123,0.00033544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002980579,"about_ca_system_score_gemma":0.0002541634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000430012,"about_ca_topic_score_gemma":0.0004801125,"domain_scores_codex":[0.999739,0.00008840115,0.00002143819,0.00003504951,0.00004782037,0.00006832818],"domain_scores_gemma":[0.9997243,0.000115309,0.00005209825,0.00003776539,0.00003244082,0.0000380979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003788212,0.0002245311,0.000156055,0.00001429701,0.00001018681,0.00002943168,0.00001071095,0.0002101955,0.9984472,0.00006006159,0.00002484454,0.0004335313],"study_design_scores_gemma":[0.00009403435,0.002972663,0.001166308,0.000003186871,0.00003662705,0.0001812084,0.0000207351,0.001066012,0.9938396,0.00004462972,0.0005712707,0.000003756011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973507,0.0002319898,0.001586909,0.0000663877,0.00002536782,0.00005161343,0.0002379622,0.0000180428,0.0004311413],"genre_scores_gemma":[0.9962682,0.0001598193,0.001657925,0.00004843463,0.00001146067,0.00003293719,0.000590171,0.00001764754,0.001213489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001753041,"threshold_uncertainty_score":0.005864501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705108054909676,"score_gpt":0.2780026145318896,"score_spread":0.2609515339827929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}