{"id":"W2548012549","doi":"10.1002/pbc.26325","title":"A phase IIa study of afuresertib, an oral pan‐AKT inhibitor, in patients with Langerhans cell histiocytosis","year":2016,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Medicine; Langerhans cell histiocytosis; Nausea; Internal medicine; Vomiting; Adverse effect; Gastroenterology; Population; Clinical trial; Diarrhea; Refractory (planetary science); Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262044,0.001100413,0.001466937,0.000263508,0.0003756686,0.0009095723,0.0006221804,0.0009141807,0.002694429],"category_scores_gemma":[0.0005922156,0.0004357053,0.0008839958,0.0004033243,0.0005659865,0.0006465723,0.0002329945,0.002232886,0.0006476266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008798233,"about_ca_system_score_gemma":0.001491455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067735,"about_ca_topic_score_gemma":0.002978351,"domain_scores_codex":[0.9997572,0.0000878774,0.00001827547,0.00005136379,0.00003026496,0.00005498818],"domain_scores_gemma":[0.9995556,0.00007045284,0.00008562543,0.00003651759,0.00003175813,0.0002198191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5510156,0.07193888,0.02534095,0.002011446,0.003565817,0.001797684,0.0007178901,0.006059333,0.1031728,0.0008702922,0.01129944,0.2222098],"study_design_scores_gemma":[0.6455045,0.3120676,0.02681403,0.00007281748,0.0008691163,0.0013514,0.00009172831,0.001441577,0.00516968,0.0002772085,0.006304136,0.00003606732],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874773,0.00480542,0.0005555033,0.0005707195,0.0001353121,0.002248518,0.001153523,0.00007405785,0.002979774],"genre_scores_gemma":[0.9888594,0.00313446,0.001481817,0.0008739399,0.0001195762,0.00147303,0.002187618,0.00001863011,0.001851529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002694429,"threshold_uncertainty_score":0.009013772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127879856081827,"score_gpt":0.2730059152331955,"score_spread":0.2617271166723772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}