{"id":"W2548441506","doi":"10.1158/2326-6066.imm2016-b034","title":"Abstract B034: Smac mimetics synergistically improve the efficacy of cancer immunotherapies including immune checkpoint blockade in preclinical models","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Oncolytic virus; Cancer research; Immune system; Cancer immunotherapy; Immune checkpoint; Cancer; Immunotherapy; Necroptosis; Immunogenic cell death; Cancer cell; Programmed cell death; T cell; Tumor necrosis factor alpha; Immunology; Biology; Medicine; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003936577,0.0005054962,0.001087405,0.0005079079,0.0004790416,0.00003309333,0.002262996,0.00102142,0.00281265],"category_scores_gemma":[0.001424978,0.0003180572,0.0003546395,0.0007783662,0.005832971,0.0002086512,0.001228546,0.002607816,0.000217939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008255028,"about_ca_system_score_gemma":0.001236111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004905427,"about_ca_topic_score_gemma":0.0004208783,"domain_scores_codex":[0.9938011,0.001252529,0.001836343,0.0009814388,0.0002932215,0.001835372],"domain_scores_gemma":[0.9912285,0.005773173,0.0005126736,0.001665804,0.0007745382,0.00004527074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002657516,0.0003842214,0.001347004,0.00006877382,0.001114602,0.00000891323,0.001122714,0.00009024292,0.8948997,0.001503854,0.0001963774,0.09660613],"study_design_scores_gemma":[0.007645381,0.000445835,0.04566169,0.0009712867,0.00008433584,0.00001491711,0.000541917,0.00002505556,0.9230161,0.002903405,0.01814347,0.0005466263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7657863,0.222557,0.0002084236,0.00586896,0.002956612,0.001222288,0.0001427442,0.00008016974,0.001177466],"genre_scores_gemma":[0.9613571,0.03383101,0.00009719811,0.00006819774,0.0001477075,0.0008806784,0.00001165377,0.0001012839,0.003505236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1955707,"threshold_uncertainty_score":0.9999272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1215056807900822,"score_gpt":0.4196001246765551,"score_spread":0.2980944438864729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}