{"id":"W2548441506","doi":"10.1158/2326-6066.imm2016-b034","title":"Abstract B034: Smac mimetics synergistically improve the efficacy of cancer immunotherapies including immune checkpoint blockade in preclinical models","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Oncolytic virus; Cancer research; Immune system; Cancer immunotherapy; Immune checkpoint; Cancer; Immunotherapy; Necroptosis; Immunogenic cell death; Cancer cell; Programmed cell death; T cell; Tumor necrosis factor alpha; Immunology; Biology; Medicine; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003367922,0.0006918979,0.0005380438,0.0006246702,0.0001661641,0.000256364,0.000378143,0.0005155302,0.002832611],"category_scores_gemma":[0.0001117913,0.0001595453,0.0003610883,0.000265048,0.0002132819,0.000299507,0.0001582134,0.001317205,0.0006189891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002944626,"about_ca_system_score_gemma":0.000433671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005437544,"about_ca_topic_score_gemma":0.0008159411,"domain_scores_codex":[0.9998111,0.00003736591,0.00001579799,0.00002960575,0.00004923154,0.00005686877],"domain_scores_gemma":[0.9998651,0.00001676369,0.00003062081,0.00001493845,0.00001777247,0.00005482848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002973154,0.001833336,0.0001638114,0.0002212526,0.00004541664,0.00005586433,0.00001959437,0.0004527361,0.9832888,0.0002082521,0.0008494524,0.009888449],"study_design_scores_gemma":[0.0003858396,0.01304352,0.001494238,0.00001663142,0.00007648265,0.0001658363,0.00001520702,0.0008167191,0.9794997,0.00005846729,0.004419883,0.000007481514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819935,0.00616647,0.004158122,0.0003982679,0.0003095393,0.0003841874,0.001381662,0.0004413922,0.00476687],"genre_scores_gemma":[0.9845374,0.00305423,0.004625448,0.0001722155,0.00006110437,0.0004027531,0.001545593,0.00006120498,0.005540058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002832611,"threshold_uncertainty_score":0.009476066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1215056807900822,"score_gpt":0.4196001246765551,"score_spread":0.2980944438864729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}