{"id":"W2548494392","doi":"10.1016/j.yjmcc.2016.10.016","title":"Structures reveal details of small molecule binding to cardiac troponin","year":2016,"lang":"en","type":"review","venue":"Journal of Molecular and Cellular Cardiology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Heart and Stroke Foundation of Canada","keywords":"Troponin I; Cardiac muscle; Troponin; Chemistry; Troponin complex; Biophysics; Troponin C; Stereochemistry; Skeletal muscle; Crystallography; Biochemistry; Biology; Cardiology; Anatomy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008421693,0.0004719851,0.005234389,0.0005571839,0.00005390446,0.00001222345,0.0001962513,0.0004512041,0.000006307411],"category_scores_gemma":[0.0002627715,0.000306458,0.002668106,0.0002229813,0.0001754118,0.00002203016,0.0001887632,0.0005231752,0.00000561626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001018028,"about_ca_system_score_gemma":0.000316117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000264735,"about_ca_topic_score_gemma":1.17185e-7,"domain_scores_codex":[0.9971693,0.000610263,0.001139907,0.0003587904,0.0003303422,0.0003914608],"domain_scores_gemma":[0.9980682,0.0001459801,0.0007546754,0.0004142215,0.0003222187,0.0002947384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000430882,0.00004289072,0.0002234346,0.01431463,0.01542882,0.01051352,0.0002246933,0.000006118981,0.08651876,0.0005863826,0.002554935,0.8691549],"study_design_scores_gemma":[0.001088367,0.001345215,0.00004748049,0.009036385,0.01124531,0.007266725,0.0001272355,5.824861e-8,0.009158148,0.00008342796,0.9600859,0.0005158083],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01002629,0.9851759,0.002634788,0.00005159822,0.0007405373,0.0005004629,0.00006494213,0.000007302877,0.0007981989],"genre_scores_gemma":[0.007574344,0.9906043,0.0007579721,0.00004889849,0.0007746344,0.00001244726,0.0000153026,0.00006551661,0.0001466078],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9575309,"threshold_uncertainty_score":0.9999387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442583483389876,"score_gpt":0.28886361760014,"score_spread":0.2644377827662412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}