{"id":"W2548573003","doi":"10.1038/nchembio.2231","title":"Inhibition of RAS function through targeting an allosteric regulatory site","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Institute for Research in Immunology and Cancer; Lunenfeld-Tanenbaum Research Institute; Université de Montréal","funders":"National Institute of General Medical Sciences; National Cancer Institute; U.S. Department of Veterans Affairs","keywords":"Allosteric regulation; Anti-apoptotic Ras signalling cascade; Effector; GTPase; Small GTPase; Cell biology; Signal transduction; Function (biology); Biology; Carcinogenesis; GTP'; Kinase; Guanine nucleotide exchange factor; Cancer research; MAPK/ERK pathway; Biochemistry; Receptor; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002543319,0.0004252128,0.0002766744,0.0002225362,0.0002662688,0.0004442749,0.0006114324,0.0004222367,0.003000486],"category_scores_gemma":[0.0002655965,0.0002442666,0.0003288378,0.0001244581,0.0004478031,0.000238019,0.0002804975,0.0009737989,0.0007032215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00044486,"about_ca_system_score_gemma":0.0003092702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004681256,"about_ca_topic_score_gemma":0.001063417,"domain_scores_codex":[0.9998291,0.00002952778,0.00001548815,0.00003096427,0.00005484109,0.00004009204],"domain_scores_gemma":[0.9998697,0.00003797698,0.00003256252,0.00002532265,0.00001160596,0.00002283534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002580991,0.00007870464,0.00009394369,0.00003753373,0.00001012532,0.00008541565,0.00001255112,0.0002908285,0.9948348,0.001379539,0.000111058,0.002807523],"study_design_scores_gemma":[0.00005564067,0.0001483944,0.0003022442,0.000003485557,0.00001365808,0.0001524517,0.000006380588,0.002419687,0.9946874,0.0001594216,0.002043422,0.000007749797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811142,0.0007440466,0.01000636,0.0005541822,0.000200471,0.00008653117,0.0001742359,0.0006525579,0.00646737],"genre_scores_gemma":[0.9957269,0.0002546881,0.002161349,0.00007060383,0.00001635649,0.0000230069,0.00006331917,0.00002998251,0.001653725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003000486,"threshold_uncertainty_score":0.01003766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007184698649611825,"score_gpt":0.2476339792713569,"score_spread":0.2404492806217451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}