{"id":"W2548624327","doi":"10.1007/s10620-016-4360-6","title":"A Data-Based Hypothesis Explicating Thiopurine Therapeutic Failure in Biologic-Naive UC","year":2016,"lang":"en","type":"letter","venue":"Digestive Diseases and Sciences","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Thiopurine methyltransferase; Transplant surgery; Hepatology; Medicine; Internal medicine; Intensive care medicine; Azathioprine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003797624,0.0004530721,0.0005571551,0.0002892531,0.0006032426,0.00009237396,0.001406228,0.0004857797,0.0002150626],"category_scores_gemma":[0.0003285645,0.0002851446,0.0001196555,0.0003401175,0.002219595,0.0002532143,0.0003088168,0.0006305311,0.0001015507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000296038,"about_ca_system_score_gemma":0.0002606196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036329,"about_ca_topic_score_gemma":0.000002674157,"domain_scores_codex":[0.9971234,0.0003922509,0.0003950877,0.001183022,0.0001055393,0.0008006569],"domain_scores_gemma":[0.9976785,0.00131111,0.0002870834,0.0006551843,0.00005613459,0.00001203146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000600679,0.001167596,0.4909846,0.0006765913,0.0008776502,0.0004582332,0.001683,0.00005442935,0.02575964,0.001381723,0.1557006,0.3206552],"study_design_scores_gemma":[0.001528237,0.0003914783,0.2756909,0.0007044244,0.0001870046,0.00002647514,0.001486762,0.00005388607,0.0003656541,0.00225603,0.7160267,0.001282456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2537649,0.2234433,0.0001665628,0.5109,0.00121195,0.001654475,0.006558877,0.0003178181,0.001982077],"genre_scores_gemma":[0.8942616,0.0006261066,0.00003808418,0.1032549,0.00007130951,0.0001388211,0.001003609,0.00002995317,0.0005756617],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6404967,"threshold_uncertainty_score":0.9999601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04836055761112559,"score_gpt":0.2709966899163251,"score_spread":0.2226361323051995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}