{"id":"W2548642620","doi":"10.1016/j.aquatox.2016.10.021","title":"Molecular initiating events of the intersex phenotype: Low-dose exposure to 17α-ethinylestradiol rapidly regulates molecular networks associated with gonad differentiation in the adult fathead minnow testis","year":2016,"lang":"en","type":"article","venue":"Aquatic Toxicology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Transcriptome; Sex reversal; Gonad; Doublesex; Endocrinology; Internal medicine; Transcription factor; Gene expression; Sexual differentiation; Gene expression profiling; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081194,0.0002023396,0.0002033095,0.0001996362,0.0001880259,0.0002223074,0.0001208282,0.0001670661,0.001916193],"category_scores_gemma":[0.0001024658,0.0001569018,0.0002148556,0.00009855848,0.0002635809,0.0002758958,0.0001721845,0.000358585,0.0002688279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090662,"about_ca_system_score_gemma":0.0001861959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009244169,"about_ca_topic_score_gemma":0.002513322,"domain_scores_codex":[0.9999285,0.00001009898,0.00000574592,0.00002152891,0.0000135983,0.00002056161],"domain_scores_gemma":[0.9999071,0.00001410105,0.00002794557,0.00001053671,0.0000128367,0.00002739659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729595,0.00001195034,0.0006838407,0.00001348077,0.000002736894,0.00007150607,0.00001639714,0.00002128533,0.9984645,0.00008009698,0.00002021505,0.0004410351],"study_design_scores_gemma":[0.00002096313,0.0003242885,0.06382252,0.000009528183,0.00001912005,0.0002349526,0.0001687172,0.000240348,0.933809,0.00008418321,0.00126203,0.00000434921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964852,0.0007566777,0.001275756,0.00008298255,0.00002047608,0.00002066117,0.0003697381,0.00003902336,0.0009494486],"genre_scores_gemma":[0.994792,0.000435323,0.0004424948,0.00004038287,0.000008452093,0.00002884157,0.0005661236,0.00001331508,0.003673033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916193,"threshold_uncertainty_score":0.006410301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008184557096780804,"score_gpt":0.2332127966606179,"score_spread":0.2250282395638371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}