{"id":"W2548695469","doi":"10.1182/blood.v118.21.2672.2672","title":"MLN9708, a Novel, Investigational Proteasome Inhibitor, in Patients with Relapsed/Refractory Lymphoma: Results of a Phase 1 Dose-Escalation Study","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Bortezomib; Proteasome inhibitor; Pharmacokinetics; Pharmacology; Pharmacodynamics; Internal medicine; Adverse effect; Cmax; Phases of clinical research; Nausea; Gastroenterology; Surgery; Toxicity; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002062526,0.0009499784,0.001701716,0.000383304,0.0003302317,0.0008859121,0.0007134659,0.0008100155,0.001531013],"category_scores_gemma":[0.0009630921,0.0004523999,0.001127473,0.0005084767,0.0004882751,0.0008451951,0.0002907998,0.002247047,0.0006212401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009993003,"about_ca_system_score_gemma":0.0008269881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004665851,"about_ca_topic_score_gemma":0.00118562,"domain_scores_codex":[0.9993568,0.0002815332,0.00005069649,0.0001130352,0.000108656,0.00008924067],"domain_scores_gemma":[0.9992641,0.0001938486,0.0001798155,0.00008616526,0.00007089451,0.0002051776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3799235,0.07482732,0.06238407,0.001370725,0.003907119,0.001242214,0.001065055,0.00518913,0.09321245,0.0003132414,0.00702533,0.3695399],"study_design_scores_gemma":[0.2943431,0.5637069,0.1119337,0.0001308849,0.002277262,0.002287029,0.0002823668,0.005852519,0.01101231,0.0003678821,0.00771537,0.0000906078],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950728,0.002146898,0.0003870193,0.0002073935,0.000025073,0.0005781796,0.0005264037,0.00005476729,0.001001579],"genre_scores_gemma":[0.9935721,0.00154884,0.001234003,0.0006058458,0.00007079662,0.0006738375,0.001545334,0.0000299071,0.0007192958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062526,"threshold_uncertainty_score":0.01090783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059746084414802,"score_gpt":0.2312924847047498,"score_spread":0.2106950238606018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}