{"id":"W2548761419","doi":"10.1016/j.ijrobp.2016.09.005","title":"In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model","year":2016,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research","keywords":"In vivo; Medicine; Tumor hypoxia; Pathology; Hypoxia (environmental); Hindlimb; Irradiation; Vascularity; Vascular permeability; Pancreatic tumor; Radiation therapy; Pancreatic cancer; Internal medicine; Chemistry; Cancer; Biology; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006143702,0.0002660366,0.0004350109,0.0002269649,0.00005496084,0.00003250672,0.0002893866,0.0001667505,0.00003390375],"category_scores_gemma":[0.0003823671,0.0002155766,0.0001463711,0.0001405339,0.00009962582,0.0001112863,0.00008017988,0.0001948368,0.000003253418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005759389,"about_ca_system_score_gemma":0.0003530507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001070665,"about_ca_topic_score_gemma":0.00001091644,"domain_scores_codex":[0.9978462,0.0003447438,0.0008251613,0.0004448617,0.0002421961,0.0002968682],"domain_scores_gemma":[0.9982547,0.0001573946,0.0009559497,0.0001940543,0.0003124034,0.0001255362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003333306,0.0002528997,0.1065674,0.000006777524,0.00007459404,0.00001502802,0.000062543,0.0003115573,0.8853946,0.0001528315,0.0005403724,0.006288011],"study_design_scores_gemma":[0.01382509,0.00132459,0.0924141,0.0003401524,0.00009936448,0.0001188241,0.0001391859,0.006028749,0.8742861,0.006475705,0.004155515,0.0007926487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887023,0.000649259,0.009170846,0.0004761477,0.0005937169,0.0002418097,0.0001191551,0.00001062292,0.00003616073],"genre_scores_gemma":[0.9968922,0.0002951099,0.0009220211,0.0009871691,0.0007621848,0.0000405617,0.0000441164,0.00003825768,0.00001837479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01415334,"threshold_uncertainty_score":0.8790959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629700805181411,"score_gpt":0.2762345045296419,"score_spread":0.2599374964778278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}