{"id":"W2548922080","doi":"10.1038/srep36182","title":"Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"European Commission; French Muscular Dystrophy Association; Muscular Dystrophy Association","keywords":"Immunogenicity; Antibody; Enzyme replacement therapy; Immune system; Medicine; Immunology; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868335,0.0001981611,0.0003787265,0.0002075136,0.0001826306,0.0003226484,0.0001085335,0.0003629409,0.001071621],"category_scores_gemma":[0.0005209089,0.00009930782,0.0002401677,0.0001363506,0.0001294125,0.000171776,0.0001332751,0.0004057118,0.0001931865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001402609,"about_ca_system_score_gemma":0.00008408708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472364,"about_ca_topic_score_gemma":0.0003382345,"domain_scores_codex":[0.999896,0.00002523113,0.00001135767,0.00002783788,0.00001582207,0.00002369825],"domain_scores_gemma":[0.9997182,0.0000522324,0.00009500129,0.00001459129,0.00002111322,0.00009880615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01503116,0.001866569,0.5284275,0.0001923209,0.0002827676,0.005474021,0.0004964748,0.0001874179,0.3894549,0.00008670312,0.0006043778,0.05789579],"study_design_scores_gemma":[0.0001199243,0.005506754,0.9750633,0.00001472232,0.0001227116,0.005411745,0.0001341803,0.0002146128,0.0124122,0.00003445046,0.0009565572,0.000009019946],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991492,0.0005805707,0.00005503525,0.00001847447,0.000004729159,0.000002730168,0.00002743981,0.000004560866,0.0001571839],"genre_scores_gemma":[0.999521,0.0001057547,0.00004960791,0.00004501405,0.000006754011,0.000003678482,0.00006475586,0.000001371915,0.0002019478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071621,"threshold_uncertainty_score":0.003584981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690711943283254,"score_gpt":0.2945455001691896,"score_spread":0.2776383807363571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}