{"id":"W2548956161","doi":"10.1161/circheartfailure.112.000061","title":"Bidirectional Regulation of Nuclear Factor-κB and Mammalian Target of Rapamycin Signaling Functionally Links Bnip3 Gene Repression and Cell Survival of Ventricular Myocytes","year":2013,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; IκB kinase; mTORC2; Cell biology; Myocyte; Transcription factor; Signal transduction; Biology; RPTOR; Cancer research; NF-κB; Programmed cell death; Proinflammatory cytokine; Immunology; Apoptosis; mTORC1; Inflammation; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250324,0.0005795253,0.0002531339,0.0002312199,0.0002081836,0.0003070333,0.0002855871,0.0001679756,0.001798123],"category_scores_gemma":[0.0001183246,0.0001397585,0.0003423951,0.00014653,0.0003696601,0.0002450258,0.0004283907,0.0006805086,0.0005908411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003922906,"about_ca_system_score_gemma":0.0003408657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003565042,"about_ca_topic_score_gemma":0.0005942267,"domain_scores_codex":[0.9997661,0.00002601983,0.00002059697,0.00005701798,0.00006919999,0.00006102285],"domain_scores_gemma":[0.9998507,0.00001345997,0.00006812447,0.00001220843,0.00001867891,0.00003671047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359282,0.0000216608,0.0002721058,0.00007215016,0.000007852426,0.00005009042,0.000008888193,0.00004328644,0.99813,0.0001352031,0.00006080835,0.001061991],"study_design_scores_gemma":[0.00003690717,0.0002446998,0.01280359,0.00002600417,0.00004195585,0.0004297539,0.00005397559,0.001083643,0.980983,0.0002258072,0.004061801,0.000008814054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723563,0.007619453,0.01339995,0.000380071,0.0001762048,0.00006805349,0.001384798,0.0003833385,0.004231942],"genre_scores_gemma":[0.9904485,0.002457939,0.004282366,0.00009840282,0.00003116834,0.0001062452,0.0008739459,0.00005640811,0.001644953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798123,"threshold_uncertainty_score":0.006015301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009410415198965804,"score_gpt":0.2009729862104189,"score_spread":0.1915625710114531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}