{"id":"W2548956161","doi":"10.1161/circheartfailure.112.000061","title":"Bidirectional Regulation of Nuclear Factor-κB and Mammalian Target of Rapamycin Signaling Functionally Links Bnip3 Gene Repression and Cell Survival of Ventricular Myocytes","year":2013,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; IκB kinase; mTORC2; Cell biology; Myocyte; Transcription factor; Signal transduction; Biology; RPTOR; Cancer research; NF-κB; Programmed cell death; Proinflammatory cytokine; Immunology; Apoptosis; mTORC1; Inflammation; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005203,0.0001281733,0.000213772,0.00009067551,0.00006401871,0.00001174481,0.00004810558,0.0002721523,0.0001650579],"category_scores_gemma":[0.00008249849,0.0001305555,0.00007935562,0.000106153,0.00008425903,0.00001923244,0.00004693294,0.00009220892,0.000002533158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001011588,"about_ca_system_score_gemma":0.00004486043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004161281,"about_ca_topic_score_gemma":0.000001369323,"domain_scores_codex":[0.9988713,0.0001019852,0.0003756818,0.0002950154,0.0002340082,0.0001220254],"domain_scores_gemma":[0.9990276,0.00003800266,0.0002577878,0.0001994793,0.0004107335,0.00006647627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003417622,0.00003673976,0.08839002,0.00009870643,0.00002694318,1.727237e-7,0.00004649996,0.002143233,0.9089177,0.00002402969,0.0001932493,0.00008855979],"study_design_scores_gemma":[0.00043286,0.0001066675,0.2354824,0.00004216667,0.00001767054,0.000007002396,0.00005141297,0.00112434,0.7612468,0.0001049948,0.001265782,0.000117888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979342,0.0005377057,0.001048579,0.00007879237,0.00009125192,0.000228819,0.00003243727,0.000009844483,0.00003842425],"genre_scores_gemma":[0.9941494,0.00001100544,0.005464502,0.00001809713,0.0001157954,0.000005119448,0.0001681359,0.00002025305,0.00004767454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1476709,"threshold_uncertainty_score":0.5323899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009410415198965804,"score_gpt":0.2009729862104189,"score_spread":0.1915625710114531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}