{"id":"W2549009828","doi":"10.1371/journal.pgen.1006344","title":"The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma","year":2016,"lang":"en","type":"letter","venue":"PLoS Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Senescence; Biology; Telomere; Carcinogenesis; Cancer research; Cellular senescence; DNA damage; Cancer; Cell cycle; Head and neck squamous-cell carcinoma; Cell; Cell biology; Cell cycle checkpoint; Head and neck cancer; Phenotype; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001177734,0.000413129,0.000732474,0.0003729511,0.001192155,0.001285449,0.0005425765,0.01215836,0.002036019],"category_scores_gemma":[0.007398909,0.0002462894,0.0005275295,0.0002836823,0.001253281,0.001511029,0.0007063322,0.009897877,0.001333084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00168346,"about_ca_system_score_gemma":0.0006383832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001225648,"about_ca_topic_score_gemma":0.002032625,"domain_scores_codex":[0.9994476,0.0001710801,0.0000896781,0.00007684223,0.0001391359,0.00007559392],"domain_scores_gemma":[0.9982658,0.001082713,0.0001414679,0.0000848658,0.0001873577,0.0002378164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004986645,0.0001350456,0.006561091,0.0002696422,0.00006953388,0.05404619,0.0004915544,0.0004286434,0.004164983,0.01316172,0.8496703,0.07050267],"study_design_scores_gemma":[0.0005854679,0.0007267386,0.01204313,0.0009651717,0.0001598098,0.08721653,0.001248827,0.0035551,0.00512404,0.03975237,0.8484943,0.0001286007],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.006969147,0.007728251,0.0003880358,0.9578217,0.02258407,0.00001545829,0.00005121283,0.00005180687,0.004390331],"genre_scores_gemma":[0.1333235,0.01645739,0.001187815,0.643694,0.1813461,0.00005193722,0.00006589518,0.00005886409,0.02381442],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01215836,"threshold_uncertainty_score":0.01221442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223665548124888,"score_gpt":0.2327704080169241,"score_spread":0.2105337525356752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}