{"id":"W2549009828","doi":"10.1371/journal.pgen.1006344","title":"The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma","year":2016,"lang":"en","type":"letter","venue":"PLoS Genetics","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Senescence; Biology; Telomere; Carcinogenesis; Cancer research; Cellular senescence; DNA damage; Cancer; Cell cycle; Head and neck squamous-cell carcinoma; Cell; Cell biology; Cell cycle checkpoint; Head and neck cancer; Phenotype; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001915415,0.0004529258,0.0007068765,0.0002078697,0.0001080568,0.00003242146,0.0003657218,0.0006008309,0.00002679262],"category_scores_gemma":[0.00009457775,0.000314764,0.0001280565,0.0002124914,0.0003830485,0.00002968934,0.0001546058,0.0009925758,0.00002717593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008751138,"about_ca_system_score_gemma":0.0002290947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005841688,"about_ca_topic_score_gemma":0.00003474981,"domain_scores_codex":[0.9971964,0.0001602679,0.0006819408,0.0006009128,0.0006277536,0.0007327481],"domain_scores_gemma":[0.9980007,0.0004014621,0.0002918262,0.0009915979,0.0001707753,0.0001435892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004506805,0.0005046064,0.355062,0.009092088,0.0001288019,0.00379521,0.003654924,0.000005831399,0.4416338,0.0000108374,0.169552,0.01610929],"study_design_scores_gemma":[0.004959285,0.001000665,0.01803876,0.002018132,0.0005933155,0.0001302909,0.0002737609,0.001730158,0.4805118,0.0001461485,0.4892156,0.001382081],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9184392,0.03287118,0.00003386873,0.04687741,0.0003415082,0.0007840968,0.0000521394,0.00003679326,0.0005637948],"genre_scores_gemma":[0.9721494,0.002854977,0.0003921064,0.02089313,0.002010748,0.00002784157,0.00002855918,0.0001220635,0.001521147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3370232,"threshold_uncertainty_score":0.9999304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223665548124888,"score_gpt":0.2327704080169241,"score_spread":0.2105337525356752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}