{"id":"W2549035745","doi":"10.18433/j31s53","title":"Substrate Specificity of Human Cytochrome P450 (CYP) 2C Subfamily and Effect of Azole Antifungal Agents on CYP2C8","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ryobi Teien Memory Foundation","keywords":"Ketoconazole; CYP2C8; Azole; CYP2C9; Tolbutamide; Miconazole; Chemistry; Cytochrome P450; Pharmacology; Itraconazole; CYP3A4; CYP2C19; Biochemistry; Metabolism; Biology; Endocrinology; Antifungal; Microbiology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003976681,0.0003491697,0.0003688695,0.0001883101,0.0002093788,0.0002861933,0.0001213022,0.0003144433,0.002139577],"category_scores_gemma":[0.0006861299,0.000139516,0.0003460747,0.0003157748,0.0002171318,0.0001837103,0.00009693609,0.0003354197,0.0003983801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002491484,"about_ca_system_score_gemma":0.0001849502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001219465,"about_ca_topic_score_gemma":0.001116982,"domain_scores_codex":[0.9994723,0.0002207616,0.00003805591,0.0001117223,0.0001004944,0.00005673674],"domain_scores_gemma":[0.9996976,0.0001234824,0.00005710681,0.00002760791,0.00006924245,0.00002505307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008247318,0.0001109369,0.007416639,0.0002231341,0.00008210375,0.0001903474,0.00004674621,0.0003195496,0.9771221,0.00007480702,0.0003447367,0.01324417],"study_design_scores_gemma":[0.00007281837,0.001755368,0.07898284,0.00002008256,0.0001227782,0.001100647,0.00006241068,0.001835544,0.9105781,0.00005731015,0.005393198,0.00001887781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800295,0.01371958,0.002017114,0.0002359413,0.00006348755,0.00006056701,0.0004965533,0.00006713358,0.003310128],"genre_scores_gemma":[0.9947274,0.002257038,0.001030211,0.00007907969,0.00004316752,0.00003959447,0.0005273921,0.00001309497,0.001283036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002139577,"threshold_uncertainty_score":0.007157564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1877786889237135,"score_gpt":0.4969228298296273,"score_spread":0.3091441409059138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}