{"id":"W2549041080","doi":"10.1038/srep35762","title":"Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Government of Ontario","keywords":"Phosphatidylserine; Sphingomyelin; Staurosporine; Ceramide; Sphingolipid; Cell biology; Biochemistry; Chemistry; Biology; Protein kinase C; Apoptosis; Signal transduction; Cholesterol; Membrane; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010397,0.0003213122,0.0002748503,0.0001997688,0.00009715671,0.0002677811,0.0002516418,0.0003034018,0.00144645],"category_scores_gemma":[0.0001663292,0.00008911117,0.0002088227,0.000176634,0.0002347832,0.0002058843,0.0001576401,0.000543638,0.0003335868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003084686,"about_ca_system_score_gemma":0.0002508883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007756559,"about_ca_topic_score_gemma":0.001729104,"domain_scores_codex":[0.9999007,0.00001898099,0.00001642098,0.00001380843,0.00003069168,0.00001936559],"domain_scores_gemma":[0.9998858,0.0000204826,0.00003421781,0.00001628034,0.00001752856,0.00002570153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001246388,0.00003356326,0.0001697377,0.00003563478,0.000007800401,0.00002498053,0.00001046454,0.00002855808,0.9979784,0.00006706655,0.00004256168,0.001476642],"study_design_scores_gemma":[0.00001018875,0.0001791494,0.001586419,0.000002411264,0.000009522465,0.0000557064,0.000009170967,0.0001325435,0.9967842,0.00001514678,0.001214542,0.00000103028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917837,0.003398623,0.002223124,0.0001964104,0.00003852384,0.00004050797,0.0007963571,0.000116111,0.001406578],"genre_scores_gemma":[0.9906951,0.00190053,0.002859938,0.00009294176,0.00001359074,0.00004589128,0.0007668412,0.00001800346,0.003607115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00144645,"threshold_uncertainty_score":0.004838884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397323844763731,"score_gpt":0.2543487464136563,"score_spread":0.240375507966019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}