{"id":"W2549041080","doi":"10.1038/srep35762","title":"Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Government of Ontario","keywords":"Phosphatidylserine; Sphingomyelin; Staurosporine; Ceramide; Sphingolipid; Cell biology; Biochemistry; Chemistry; Biology; Protein kinase C; Apoptosis; Signal transduction; Cholesterol; Membrane; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009917568,0.0001153954,0.0002771062,0.0001772197,0.00007295019,0.00001414213,0.00003378931,0.00006555238,0.0002060438],"category_scores_gemma":[0.00264504,0.00007799917,0.00004557528,0.0003024682,0.0002382774,0.0001258358,0.00004586449,0.00006523036,0.000006685648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003515394,"about_ca_system_score_gemma":0.000148397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008857731,"about_ca_topic_score_gemma":0.0001109629,"domain_scores_codex":[0.9983983,0.00003999876,0.0005696951,0.0005352589,0.000244257,0.000212494],"domain_scores_gemma":[0.998841,0.0001132491,0.0003220433,0.0004211105,0.0001598621,0.0001426812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003810535,0.0001083404,0.1467542,0.0001478315,0.000008507598,0.000358448,0.000124652,0.000002895282,0.8349308,0.00003262215,0.0002120973,0.01693851],"study_design_scores_gemma":[0.0005723099,0.0001450279,0.132596,0.000683892,0.00001903188,0.0003871094,0.00007590748,0.00004944213,0.859563,0.0004145067,0.005356182,0.0001375596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977507,0.0001012979,0.0002099363,0.0003369678,0.0009432276,0.0003686658,0.000003559224,0.00003678299,0.0002488694],"genre_scores_gemma":[0.9961353,0.00004231219,0.001969494,0.00002169977,0.00006708816,0.00003946524,0.000009437972,0.00001173213,0.001703492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02463214,"threshold_uncertainty_score":0.3180714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397323844763731,"score_gpt":0.2543487464136563,"score_spread":0.240375507966019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}