{"id":"W2549069008","doi":"10.18632/oncotarget.13654","title":"The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; University of Tokyo; CancerCare Manitoba Foundation; Strong; Research Manitoba","keywords":"Synthetic lethality; Colorectal cancer; Medicine; PARP1; Cancer research; Growth inhibition; Pharmacology; Cancer; Lethality; Oncology; Apoptosis; Biology; Internal medicine; Toxicology; Poly ADP ribose polymerase; Genetics; DNA repair; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001835392,0.0003861271,0.0003353101,0.0002199068,0.0001420892,0.0003569126,0.000226981,0.0003059793,0.002571695],"category_scores_gemma":[0.0001722487,0.0001578156,0.0003816003,0.00017004,0.0002233978,0.00020486,0.000246354,0.0008484643,0.0008593971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420664,"about_ca_system_score_gemma":0.0002854311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006253506,"about_ca_topic_score_gemma":0.0008926147,"domain_scores_codex":[0.9998577,0.00002305379,0.00001763676,0.00002338816,0.000043069,0.00003520118],"domain_scores_gemma":[0.9999021,0.00001183199,0.00003131056,0.00001535911,0.00001466323,0.00002469164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005081968,0.0001569109,0.0004252914,0.0002220492,0.00003006986,0.00009675018,0.00002849323,0.0002421597,0.9864563,0.0002384904,0.001477604,0.01011769],"study_design_scores_gemma":[0.0001334247,0.002155356,0.009542298,0.0000555544,0.00005784076,0.0007109672,0.00008220445,0.002134385,0.9725735,0.0001796918,0.01235738,0.00001742852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659182,0.01421333,0.006028804,0.001211999,0.0004695517,0.0001043158,0.001436455,0.0005829077,0.01003437],"genre_scores_gemma":[0.9896308,0.003428041,0.001496415,0.0002863613,0.00002232815,0.00005727302,0.001119833,0.00003926014,0.003919734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002571695,"threshold_uncertainty_score":0.008603215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008912059232885041,"score_gpt":0.2622032173210953,"score_spread":0.2532911580882103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}