{"id":"W2549281714","doi":"10.1182/blood.v108.11.3690.3690","title":"Dramatically Enhanced Immunopotency and Anti-Tumor Activity of Liposome-Encapsulated CpG Oligonucleotides (ODN) in Mice Is Paralleled by Vigorous and Broad-Based Immune Responses in Cynomolgus Monkeys after Both Intravenous (IV) and Subcutaneous (SC) Administration.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"","keywords":"CpG Oligodeoxynucleotide; Immune system; Immunology; Immunotherapy; CpG site; Biology; Antibody; Monoclonal antibody; Antigen; Cancer research; Medicine; Pharmacology; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003511163,0.000801935,0.0003670297,0.0006411692,0.0001589305,0.000309415,0.0002208522,0.0005484847,0.001533492],"category_scores_gemma":[0.0001354424,0.0001972849,0.0003490891,0.0001673005,0.0003314009,0.0002926164,0.0002404323,0.0009626627,0.0005137194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266982,"about_ca_system_score_gemma":0.0002657576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008747614,"about_ca_topic_score_gemma":0.001322867,"domain_scores_codex":[0.9997596,0.00003221978,0.00001783902,0.00007726927,0.00004447483,0.00006852824],"domain_scores_gemma":[0.9998079,0.00003228901,0.00006538989,0.00002099796,0.0000209293,0.00005245874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009992774,0.00005291037,0.00005341172,0.00001901628,0.000003090574,0.00001343089,0.00001849481,0.00002822995,0.9990689,0.00004220511,0.00002196993,0.0005784358],"study_design_scores_gemma":[0.00002327667,0.001129722,0.001185244,0.000006591674,0.00001348063,0.00009581664,0.000009746816,0.0005029543,0.9960811,0.0000335492,0.0009150014,0.000003479805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892758,0.001111024,0.005756337,0.0001620936,0.00006212766,0.0001746418,0.0005280453,0.0002998597,0.002630024],"genre_scores_gemma":[0.9868046,0.000828388,0.005238982,0.0001552971,0.00002274133,0.0002492311,0.0006738149,0.0001017173,0.005925294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001533492,"threshold_uncertainty_score":0.005129993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002985193119698676,"score_gpt":0.2033669540449808,"score_spread":0.2003817609252821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}