{"id":"W2549347500","doi":"10.1083/jcb.201606081","title":"GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Worldwide Cancer Research","keywords":"Chromosome segregation; Chromosome instability; Mitosis; Microtubule; Cell biology; Kinetochore; Chromosome; Biology; Kinesin; Multipolar spindles; Spindle apparatus; Centromere; Genetics; Cell division; Cell; Chemistry; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007989337,0.000159201,0.0001884514,0.00002274145,0.0001678382,0.00001535043,0.0002553626,0.0001421261,0.00001382734],"category_scores_gemma":[0.00008320076,0.00007446265,0.0001044536,0.00003492238,0.0002614198,0.000007498337,0.0001092924,0.00009052437,0.000001621184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002381384,"about_ca_system_score_gemma":0.00006507302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001415735,"about_ca_topic_score_gemma":0.00002250503,"domain_scores_codex":[0.9988834,0.0002268628,0.0004002304,0.0001729773,0.00005969653,0.0002568252],"domain_scores_gemma":[0.9990451,0.0001727824,0.0003760048,0.000218324,0.0001274622,0.00006033251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002110577,0.00004757144,0.000322451,0.00001966927,0.00004292118,2.799791e-7,0.00008245222,8.535483e-7,0.9954028,0.00002383283,0.001050534,0.002795636],"study_design_scores_gemma":[0.0009280089,0.0006356317,0.00003849909,0.00001772404,0.00005489601,0.00007477647,0.0001506712,0.000007957989,0.9833262,0.0003344117,0.01431699,0.0001142348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889722,0.004688311,0.004032692,0.001709952,0.0001438416,0.0003103226,0.00009318553,0.000002968146,0.00004646059],"genre_scores_gemma":[0.9970829,0.001737031,0.0002892587,0.0004257269,0.0002175854,0.00001165539,0.00002197813,0.00001682771,0.000197009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01326645,"threshold_uncertainty_score":0.3036499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007563776631560911,"score_gpt":0.2228580650498654,"score_spread":0.2152942884183044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}