{"id":"W2549389531","doi":"10.1182/blood.v116.21.438.438","title":"Genetic Screen to Isolate “Lariat” Peptides for Characterizing ABL Kinase Activity and Conformation","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; University of Saskatchewan","funders":"","keywords":"ABL; Mutant; Biochemistry; Mutagenesis; Saturated mutagenesis; Chemistry; Peptide; Kinase; Protein kinase domain; In vitro; Biology; Stereochemistry; Gene; Tyrosine kinase; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002201676,0.0006031609,0.0005148462,0.000517959,0.0001452957,0.000275246,0.0003133612,0.0003182376,0.001103575],"category_scores_gemma":[0.0002857897,0.0001800199,0.0004223454,0.0004054924,0.0001892664,0.0001268565,0.0003098498,0.0005590043,0.0005133731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770366,"about_ca_system_score_gemma":0.0002389458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003874407,"about_ca_topic_score_gemma":0.0006295344,"domain_scores_codex":[0.9997067,0.00005180724,0.00002664718,0.0000447185,0.0001180632,0.00005195116],"domain_scores_gemma":[0.9996531,0.0001046607,0.00009552255,0.00002615212,0.00006130736,0.00005926951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002735619,0.00003871925,0.0001127242,0.00000898262,0.000004482206,0.00004968834,0.000004690902,0.00007577724,0.9989442,0.00001798608,0.00001391259,0.0007013692],"study_design_scores_gemma":[0.00001307303,0.0004328986,0.001824341,0.000002459171,0.00001935997,0.0003146216,0.00001405287,0.00103615,0.9956433,0.00001117443,0.0006836272,0.000005058231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982672,0.0005642223,0.01363799,0.0001081754,0.0000287038,0.0003133629,0.0008921669,0.0001834177,0.001599902],"genre_scores_gemma":[0.9771822,0.0004445003,0.01684574,0.0001489314,0.00001734889,0.0001491314,0.003105851,0.00008578421,0.002020474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103575,"threshold_uncertainty_score":0.003691852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250281735645602,"score_gpt":0.2577570151845734,"score_spread":0.2452541978281174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}