{"id":"W2549543448","doi":"10.1007/s12033-016-9987-1","title":"Virus-Like Particles Derived from HIV-1 for Delivery of Nuclear Proteins: Improvement of Production and Activity by Protein Engineering","year":2016,"lang":"en","type":"article","venue":"Molecular Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; National Research Council Canada; PROTEO","funders":"Canadian Institutes of Health Research","keywords":"Transactivation; Gene delivery; Transfection; Green fluorescent protein; Insertional mutagenesis; Reporter gene; Gene; KLF4; Molecular biology; Biology; Recombinant DNA; Cell culture; Group-specific antigen; Cell biology; Chemistry; Gene expression; Transcription factor; Biochemistry; Genome; Genetics; SOX2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407108,0.0001485539,0.0001903481,0.00007420209,0.00002931506,0.000004428829,0.0001770646,0.0002768821,0.00000548024],"category_scores_gemma":[0.0001476027,0.0001269409,0.00006226759,0.00007896878,0.0002145664,0.000006079376,0.000152184,0.00006689096,0.000001073603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001823144,"about_ca_system_score_gemma":0.00003506595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004160825,"about_ca_topic_score_gemma":0.00003036909,"domain_scores_codex":[0.9990057,0.00003350493,0.0001921071,0.0004165136,0.0001099671,0.00024216],"domain_scores_gemma":[0.9993113,0.000007610058,0.0001168948,0.0004410529,0.00008252226,0.00004063026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00114329,0.0001084321,0.00002213048,0.00004393582,0.0001122269,7.199691e-7,0.000008602377,0.000007392764,0.9572854,0.00001776638,0.00003358175,0.04121651],"study_design_scores_gemma":[0.0007491417,0.002361435,0.0000419721,0.00004019928,0.00001396663,0.000001084734,0.00001200683,0.00007369636,0.9955816,0.00008977807,0.0008926517,0.0001425254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748462,0.0005345771,0.02242703,0.00105025,0.00002256834,0.0009599177,0.0001319358,0.00002685648,6.774811e-7],"genre_scores_gemma":[0.9963741,0.0001544545,0.00320121,0.00002396822,0.00001794616,0.0001645824,0.0000137641,0.00003567599,0.0000143525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04107398,"threshold_uncertainty_score":0.5176501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006371228070871146,"score_gpt":0.2168919797470183,"score_spread":0.2105207516761471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}