{"id":"W2549543448","doi":"10.1007/s12033-016-9987-1","title":"Virus-Like Particles Derived from HIV-1 for Delivery of Nuclear Proteins: Improvement of Production and Activity by Protein Engineering","year":2016,"lang":"en","type":"article","venue":"Molecular Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; National Research Council Canada; PROTEO","funders":"Canadian Institutes of Health Research","keywords":"Transactivation; Gene delivery; Transfection; Green fluorescent protein; Insertional mutagenesis; Reporter gene; Gene; KLF4; Molecular biology; Biology; Recombinant DNA; Cell culture; Group-specific antigen; Cell biology; Chemistry; Gene expression; Transcription factor; Biochemistry; Genome; Genetics; SOX2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005759913,0.0004130627,0.0004034387,0.0004015071,0.0002458751,0.0006504829,0.0003891968,0.0005010401,0.0003714058],"category_scores_gemma":[0.0004912192,0.0002545005,0.0002960951,0.0003974873,0.000476527,0.0004540165,0.0002516742,0.00114752,0.0004324832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004239393,"about_ca_system_score_gemma":0.0003893648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004441629,"about_ca_topic_score_gemma":0.0004668982,"domain_scores_codex":[0.9997712,0.00005178529,0.00002010905,0.00003086673,0.00009749678,0.00002850613],"domain_scores_gemma":[0.999828,0.00006711214,0.00003403184,0.00001871582,0.00002562647,0.00002642275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005044628,0.00002537179,0.00006467646,0.00004340504,0.000003978209,0.00003962112,0.00003219237,0.0001109308,0.9959573,0.0006208029,0.00003211197,0.00301913],"study_design_scores_gemma":[0.000007918183,0.00007106453,0.000205075,0.000004200561,0.00001084678,0.0001196732,0.000006862655,0.0004848686,0.9965771,0.0001297354,0.002378891,0.000003828015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.891898,0.009969188,0.09402601,0.0004193427,0.0001407784,0.0002090647,0.0002920145,0.0003049977,0.00274063],"genre_scores_gemma":[0.9117721,0.006799159,0.0739831,0.000109752,0.00004172048,0.0001124424,0.001238251,0.0001464836,0.005796941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006504829,"threshold_uncertainty_score":0.003075898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006371228070871146,"score_gpt":0.2168919797470183,"score_spread":0.2105207516761471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}