{"id":"W2549874910","doi":"10.1038/srep37160","title":"11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Wenzhou Municipal Science and Technology Bureau","keywords":"11β-hydroxysteroid dehydrogenase type 1; Insulin resistance; Internal medicine; Endocrinology; Glucocorticoid; Adipose tissue; Insulin; GLUT4; Cortisone; Chemistry; Biology; Dehydrogenase; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002110808,0.0003802269,0.000321295,0.0002842885,0.0004242166,0.0004102292,0.0001810412,0.000213911,0.002040851],"category_scores_gemma":[0.0001056154,0.0001716607,0.0005513176,0.0002539614,0.0003878873,0.000312957,0.0002903061,0.0008741523,0.0004249559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002728072,"about_ca_system_score_gemma":0.0003531321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008078492,"about_ca_topic_score_gemma":0.001453368,"domain_scores_codex":[0.9998268,0.00002479176,0.00001728514,0.00003823423,0.00004490107,0.00004789522],"domain_scores_gemma":[0.9999033,0.0000108236,0.00002630752,0.000009662632,0.00001747434,0.00003230121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005788179,0.00006364891,0.001038749,0.0001981415,0.00001944041,0.0002691003,0.00006978875,0.0000545005,0.9949603,0.0001258902,0.0001267431,0.002494866],"study_design_scores_gemma":[0.0001074677,0.0005182213,0.04854323,0.00003268547,0.00008631694,0.001702267,0.0003549427,0.0007962912,0.9411843,0.0004203157,0.006228568,0.00002536027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747525,0.01386659,0.006058909,0.0007262001,0.0003288111,0.00005102972,0.0006890602,0.0001065707,0.003420303],"genre_scores_gemma":[0.9869757,0.007130554,0.001923102,0.000214895,0.0000730834,0.00003927243,0.0005240798,0.00001458443,0.003104694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040851,"threshold_uncertainty_score":0.006827354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542131685264188,"score_gpt":0.270603966532744,"score_spread":0.2451826496801021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}