{"id":"W2549892900","doi":"10.18632/oncotarget.13343","title":"A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Cancer Institute; National Institutes of Health; Central South University","keywords":"Carcinogenesis; Cancer research; PTEN; Prostate cancer; Prostate; Transforming growth factor; Transforming growth factor beta; Tumor progression; Cancer; Biology; Signal transduction; Medicine; Internal medicine; Endocrinology; PI3K/AKT/mTOR pathway; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002834239,0.0003087925,0.0002746134,0.0001218418,0.00008213755,0.00003511517,0.0002027441,0.0001116971,0.00004805112],"category_scores_gemma":[0.00009030871,0.0002292788,0.0001001263,0.0001399323,0.00009644275,0.00001182442,0.0001978389,0.00008512136,0.00003225068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006742432,"about_ca_system_score_gemma":0.0001577621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007753444,"about_ca_topic_score_gemma":0.00004761445,"domain_scores_codex":[0.9980354,0.00007140225,0.0004347702,0.0007072919,0.0002766917,0.0004744007],"domain_scores_gemma":[0.9990848,0.00002861966,0.0001660493,0.0003987567,0.00008428469,0.0002375219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004451693,0.0005263357,0.07017323,0.00007740195,0.00001493178,0.00002031946,0.0001123352,0.00003112341,0.9273224,0.000007447283,0.0006674268,0.0006018213],"study_design_scores_gemma":[0.003573923,0.0005765221,0.07751355,0.0001433852,0.00001805373,0.000008868017,0.00004495027,0.00001291754,0.8855145,0.000009347932,0.03216984,0.000414155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972014,0.001211304,0.0002597974,0.0002509977,0.0001964346,0.0004505938,0.0002667026,0.00003266243,0.0001300349],"genre_scores_gemma":[0.9960766,0.000306044,0.0009861721,0.0001558921,0.0001560448,0.00008300298,0.0001149721,0.00005335988,0.002067882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04180796,"threshold_uncertainty_score":0.9349718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00933233074263237,"score_gpt":0.2171875904132496,"score_spread":0.2078552596706172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}