{"id":"W2549925369","doi":"10.1002/eji.201646583","title":"Local checkpoint inhibition of CTLA‐4 as a monotherapy or in combination with anti‐PD1 prevents the growth of murine bladder cancer","year":2016,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; University of British Columbia","funders":"Seventh Framework Programme; Vetenskapsrådet; Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning; U.S. Food and Drug Administration; Lunds Universitet; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden","keywords":"Biology; Bladder cancer; Cancer research; CTLA-4; Cancer; Pharmacology; Immunology; Immune system; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249574,0.0005355673,0.0004276237,0.0002260802,0.0001127163,0.0002110877,0.0002753689,0.0002383971,0.001328919],"category_scores_gemma":[0.00006952509,0.0001166269,0.0003022769,0.0001046735,0.0002316599,0.0001732667,0.0001633678,0.00108855,0.0002714705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002078993,"about_ca_system_score_gemma":0.0002656965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004556852,"about_ca_topic_score_gemma":0.001080785,"domain_scores_codex":[0.9998857,0.00001669683,0.000007405662,0.00002324833,0.00002106964,0.00004591411],"domain_scores_gemma":[0.9999202,0.00000946564,0.00002150292,0.00001015503,0.000005007994,0.00003370126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004389091,0.0004625768,0.0001440487,0.00007879832,0.000008833561,0.00001972641,0.00001046256,0.0002074322,0.9947848,0.00004882705,0.00006114947,0.003734461],"study_design_scores_gemma":[0.0001176906,0.006179382,0.001657169,0.00001117948,0.00003537961,0.00009610939,0.00001211195,0.0009588263,0.9900113,0.00002419154,0.0008925655,0.000004164188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965901,0.001342532,0.001098722,0.00007439397,0.00004184905,0.00003039543,0.000114115,0.0001242588,0.0005837153],"genre_scores_gemma":[0.9961568,0.0008245223,0.0009481672,0.00003709017,0.00002492031,0.00005873194,0.0001902683,0.0000170101,0.001742539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328919,"threshold_uncertainty_score":0.004445672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307994296886815,"score_gpt":0.2568991713400686,"score_spread":0.2438192283712004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}