{"id":"W2549925369","doi":"10.1002/eji.201646583","title":"Local checkpoint inhibition of CTLA‐4 as a monotherapy or in combination with anti‐PD1 prevents the growth of murine bladder cancer","year":2016,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; University of British Columbia","funders":"Seventh Framework Programme; Vetenskapsrådet; Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning; U.S. Food and Drug Administration; Lunds Universitet; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden","keywords":"Biology; Bladder cancer; Cancer research; CTLA-4; Cancer; Pharmacology; Immunology; Immune system; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000695218,0.0001120836,0.0003370246,0.0001846554,0.00001927529,0.00000291424,0.0001246689,0.00003246238,0.0002790242],"category_scores_gemma":[0.00004546724,0.00005043393,0.00009253548,0.0002166643,0.0003670448,0.00009282409,0.00002122485,0.0001607701,0.000002289355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008554517,"about_ca_system_score_gemma":0.0001696843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009555608,"about_ca_topic_score_gemma":0.00001623365,"domain_scores_codex":[0.9986017,0.0003435008,0.0006437104,0.00009514151,0.0001819059,0.0001340334],"domain_scores_gemma":[0.9988169,0.00006723106,0.0006935829,0.0001552783,0.0002442993,0.00002267128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02735225,0.0005643552,0.006249548,0.00004987422,0.0008270659,0.000167722,0.001099782,0.000004105921,0.8816084,0.0001032918,0.0001864914,0.08178712],"study_design_scores_gemma":[0.02414467,0.008410524,0.3941814,0.002073712,0.00008278364,0.000715425,0.0002873384,0.000004204077,0.5686718,0.00009160767,0.001226781,0.0001097948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933832,0.001504376,0.001240611,0.003179264,0.0001092069,0.0001896635,0.000003312364,0.000003883978,0.0003864926],"genre_scores_gemma":[0.9955747,0.003713236,0.00008368609,0.0001999824,0.00003727286,0.000002193812,8.40867e-7,0.00002272235,0.0003653276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3879319,"threshold_uncertainty_score":0.3055119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307994296886815,"score_gpt":0.2568991713400686,"score_spread":0.2438192283712004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}