{"id":"W2550105561","doi":"10.1152/ajpendo.00275.2016","title":"Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis and<i>N</i>-linked protein glycosylation","year":2016,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Glycosylation; Glucosamine; Chemistry; Unfolded protein response; Biosynthesis; Oligosaccharide; Biochemistry; Cell biology; Biology; Endoplasmic reticulum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428694,0.0006711294,0.00035518,0.0001441477,0.0001114366,0.0003136747,0.0002418638,0.0003366008,0.0007368543],"category_scores_gemma":[0.0000814278,0.0001485111,0.0004473044,0.0001723433,0.0002674545,0.0002001991,0.000221128,0.0004991849,0.0002292657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003342024,"about_ca_system_score_gemma":0.0002233044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008364354,"about_ca_topic_score_gemma":0.001280842,"domain_scores_codex":[0.9998688,0.00003234615,0.00002118546,0.0000202059,0.00002521012,0.0000321792],"domain_scores_gemma":[0.9999239,0.000008137633,0.00002920787,0.000009470786,0.000007554902,0.00002170259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001000089,0.00002597772,0.00007519054,0.00004660759,0.000005974334,0.0000463803,0.000007190222,0.0000267887,0.9990603,0.00004159177,0.00002310407,0.0005408011],"study_design_scores_gemma":[0.00002077712,0.000473156,0.002705383,0.00001066148,0.00001555249,0.0001344031,0.00002050371,0.0003523802,0.9944348,0.0000378524,0.001789988,0.000004640789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990703,0.003144347,0.002712825,0.0002016694,0.0000947928,0.00008089212,0.0005194903,0.0001215884,0.002421447],"genre_scores_gemma":[0.9887917,0.0030519,0.004111689,0.0002733705,0.0000228623,0.00007474317,0.0009006334,0.00002722147,0.002745846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008364354,"threshold_uncertainty_score":0.002465069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005892533296047167,"score_gpt":0.2322812368408275,"score_spread":0.2263887035447803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}