{"id":"W2550148757","doi":"10.1182/blood.v118.21.1834.1834","title":"Bortezomib Impairs Myeloma Cells (MM) Homologous Recombination Through Inhibition of the E2-Ubiquitin-Conjugating Enzyme UBC13","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"RAD51; Bortezomib; Homologous recombination; DNA repair; Biology; Molecular biology; Transfection; Proteasome; Genome instability; DNA damage; Proteasome inhibitor; Ubiquitin-conjugating enzyme; DNA; Ubiquitin; Cell biology; Gene; Ubiquitin ligase; Genetics; Multiple myeloma; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001425918,0.0003122539,0.0002857906,0.0001242286,0.00009918914,0.000190348,0.0001681885,0.000236886,0.001866688],"category_scores_gemma":[0.00005403865,0.000130795,0.0002145436,0.0001609885,0.00009326192,0.00007616615,0.000106778,0.0005252608,0.0005794974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389252,"about_ca_system_score_gemma":0.0002116322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006513465,"about_ca_topic_score_gemma":0.0009494238,"domain_scores_codex":[0.9998435,0.00002142496,0.00002318637,0.00003297221,0.00004242923,0.00003645979],"domain_scores_gemma":[0.9999374,0.00001078852,0.00002284913,0.00000677243,0.000005017675,0.0000171861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272998,0.00003496557,0.00008515378,0.00002286656,0.000003817983,0.00001993299,0.000004035537,0.00004246365,0.9989105,0.00002853494,0.00005670879,0.0006637249],"study_design_scores_gemma":[0.00002662229,0.0005649384,0.002881671,0.000003075693,0.0000127297,0.0001808495,0.000008830639,0.0004655371,0.9932899,0.00001380967,0.002550139,0.000001876045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920928,0.00236477,0.001960558,0.0001456893,0.00005075291,0.00004054854,0.001450653,0.0002721526,0.001622194],"genre_scores_gemma":[0.9914159,0.001091952,0.002100697,0.00006610862,0.00001378814,0.0000437101,0.001455827,0.00003004366,0.003781883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001866688,"threshold_uncertainty_score":0.006244719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311816400525781,"score_gpt":0.2140849567885244,"score_spread":0.2009667927832666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}