{"id":"W2550207442","doi":"10.1182/blood.v108.11.2247.2247","title":"Systems Analysis Reveals Regulators of Apoptosis, Cell Cycle, Signal Transduction and Transcription as Novel Direct Targets of the Acute Promyelocytic Leukemia Fusion Protein NuMA-RAR α","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Signal transduction; Acute promyelocytic leukemia; Retinoid; Fusion protein; Cell biology; Transcription factor; Fusion gene; Retinoic acid; Transgene; Gene; Cancer research; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002244318,0.0001812926,0.0003072981,0.00007419815,0.00008268188,0.00001568491,0.0001651725,0.0002116247,0.000006820607],"category_scores_gemma":[0.00001008314,0.0001391326,0.0002077763,0.0003455136,0.000122643,0.000009277544,0.00002468471,0.00008017632,2.736082e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002231208,"about_ca_system_score_gemma":0.0001152038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002027582,"about_ca_topic_score_gemma":0.000006815367,"domain_scores_codex":[0.9987161,0.00009232795,0.000423768,0.0003500259,0.000245874,0.0001718894],"domain_scores_gemma":[0.9992502,0.000006015131,0.0002845114,0.0003034252,0.0001186392,0.00003718025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006316062,0.000179218,0.001475676,0.0003350272,0.0002822664,3.581853e-7,0.00006031368,0.0009814725,0.9965215,0.00004253714,0.00001519223,0.00004324317],"study_design_scores_gemma":[0.0009872511,0.0001965328,0.001790772,0.00006983534,0.001154875,0.00001013763,0.00005291033,0.000175324,0.9952463,0.00005905864,0.0001008837,0.0001561304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950638,0.002387329,0.001343782,0.00001449757,0.00005147564,0.0005204182,0.0000398369,0.00001020279,0.0005686939],"genre_scores_gemma":[0.9987191,0.0001322051,0.0003676999,0.0000040978,0.00007798547,0.00004640878,0.00008075037,0.00001925583,0.0005525086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003655324,"threshold_uncertainty_score":0.5673661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002957362293549714,"score_gpt":0.1847596980606966,"score_spread":0.1818023357671469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}