{"id":"W2550207442","doi":"10.1182/blood.v108.11.2247.2247","title":"Systems Analysis Reveals Regulators of Apoptosis, Cell Cycle, Signal Transduction and Transcription as Novel Direct Targets of the Acute Promyelocytic Leukemia Fusion Protein NuMA-RAR α","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Signal transduction; Acute promyelocytic leukemia; Retinoid; Fusion protein; Cell biology; Transcription factor; Fusion gene; Retinoic acid; Transgene; Gene; Cancer research; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002260185,0.0003705482,0.0004132003,0.0003415008,0.0002327135,0.0004196805,0.0002650832,0.0001449931,0.001118686],"category_scores_gemma":[0.0002118565,0.0001395788,0.0004685437,0.0002660248,0.0002259855,0.0001991753,0.0002005254,0.0002194519,0.0002252924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005740793,"about_ca_system_score_gemma":0.0002808213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008116432,"about_ca_topic_score_gemma":0.001299627,"domain_scores_codex":[0.9997802,0.00004387596,0.00001088117,0.00006623891,0.00007865533,0.00002016823],"domain_scores_gemma":[0.9999046,0.00004619335,0.00001849376,0.00001194298,0.00001270638,0.000005942404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002005138,0.00006049731,0.00324817,0.0001330115,0.00003759894,0.00007526327,0.00002518387,0.01763628,0.9729424,0.00128337,0.00006644191,0.004291385],"study_design_scores_gemma":[0.00003557361,0.000721922,0.01274658,0.000007369747,0.0001112161,0.0001581315,0.00006571729,0.1888983,0.7929062,0.001834102,0.0024962,0.00001875069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445696,0.000711744,0.0511122,0.0000683515,0.00001292418,0.00006277193,0.0008227724,0.000502802,0.002136842],"genre_scores_gemma":[0.9837282,0.0003590813,0.01384581,0.00001678159,0.000004071478,0.00007768908,0.001013484,0.00001971769,0.0009351429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118686,"threshold_uncertainty_score":0.004165292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002957362293549714,"score_gpt":0.1847596980606966,"score_spread":0.1818023357671469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}