{"id":"W2550228008","doi":"10.1182/blood.v124.21.436.436","title":"Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; BC Cancer Agency; Université de Moncton; University of British Columbia; Atlantic Cancer Research Institute; McMaster University; Dalhousie University","funders":"","keywords":"Decitabine; Biology; Epigenetics; Cancer research; DNA methylation; Myeloid leukemia; Myeloid; DNA methyltransferase; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005051991,0.0007587876,0.00044428,0.0005881133,0.0004071574,0.00032813,0.0005798982,0.0008513794,0.003279247],"category_scores_gemma":[0.0002250079,0.0002389446,0.0005678561,0.000183745,0.0005459966,0.000379943,0.0002664743,0.001697044,0.0005370045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000951023,"about_ca_system_score_gemma":0.0007751993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003784203,"about_ca_topic_score_gemma":0.006554378,"domain_scores_codex":[0.9997491,0.00002705527,0.00002022932,0.00005602438,0.0000882426,0.00005934286],"domain_scores_gemma":[0.999688,0.00004726705,0.00007691071,0.00002865459,0.00005097994,0.0001081473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000455959,0.0004538119,0.0002848975,0.00006263024,0.00001752972,0.00009801873,0.0000297904,0.000346684,0.9953128,0.000282897,0.0002999822,0.002354826],"study_design_scores_gemma":[0.0001808743,0.009964119,0.002028955,0.00001643232,0.00006910894,0.0001757059,0.00005092859,0.001563447,0.9813505,0.0001446018,0.004437523,0.00001768783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97484,0.001523438,0.01243314,0.0006476476,0.0002159953,0.001078818,0.00298943,0.000536545,0.005734956],"genre_scores_gemma":[0.976181,0.001452713,0.00817357,0.0001983985,0.00002095525,0.001028709,0.001742675,0.00005370641,0.01114838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003784203,"threshold_uncertainty_score":0.01097018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958261617507553,"score_gpt":0.2835805886970638,"score_spread":0.2639979725219883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}