{"id":"W2550260109","doi":"10.1182/blood.v108.11.241.241","title":"A Novel Transgenic Mouse Model of Multiple Myeloma Reliably Predicts Drug Response.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Multiple myeloma; Somatic hypermutation; Paraproteinemia; Plasma cell; Immunology; Germinal center; Carfilzomib; Monoclonal; Biology; Genetically modified mouse; Cancer research; Monoclonal antibody; Antibody; Transgene; B cell; Bortezomib; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007190072,0.001059752,0.0006017628,0.001655351,0.0002889074,0.0006726515,0.0006635231,0.00133246,0.003123693],"category_scores_gemma":[0.0003931279,0.0005112542,0.0005887923,0.000551397,0.0005254757,0.0006879744,0.0003556328,0.002139158,0.001351571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006122289,"about_ca_system_score_gemma":0.0003469563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007523309,"about_ca_topic_score_gemma":0.001021203,"domain_scores_codex":[0.9993255,0.00008700682,0.00009614158,0.0001893813,0.0001974656,0.0001045052],"domain_scores_gemma":[0.9989325,0.0001733238,0.0004662908,0.0001152379,0.0001111553,0.0002015106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006059142,0.0004300398,0.00121421,0.0000642966,0.00001978433,0.000181771,0.00003177499,0.0001789795,0.9935166,0.0002992733,0.0004152487,0.003042183],"study_design_scores_gemma":[0.0003991031,0.004776748,0.01515995,0.00007538348,0.0002176161,0.003340248,0.00009493897,0.007087139,0.9561063,0.000660223,0.01202153,0.00006072455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471145,0.003489721,0.03041605,0.001396856,0.0003593322,0.0003808956,0.009462706,0.002554797,0.004825156],"genre_scores_gemma":[0.9507777,0.002353908,0.02032841,0.0003859344,0.00009765024,0.0007009835,0.008117577,0.0004456853,0.01679216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003123693,"threshold_uncertainty_score":0.01044983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392214032369413,"score_gpt":0.2625121457514105,"score_spread":0.2385900054277164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}