{"id":"W2550293882","doi":"10.1039/c6nr06701h","title":"Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery","year":2016,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Cationic polymerization; Endosome; Protonation; Molecular switch; Gene knockdown; Biophysics; Gene delivery; Chemistry; In vivo; Ionic bonding; Drug delivery; Nanotechnology; Combinatorial chemistry; Materials science; Molecule; Biochemistry; Gene; Transfection; Cell; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001818221,0.0003172948,0.0001199821,0.0001770175,0.0001141854,0.0003125824,0.0002261418,0.000398293,0.000903263],"category_scores_gemma":[0.0001801156,0.0001381296,0.0001389335,0.0001367301,0.0002549721,0.0003284762,0.0002906351,0.0003353787,0.0003995118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003287043,"about_ca_system_score_gemma":0.0001812488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002187333,"about_ca_topic_score_gemma":0.0002419852,"domain_scores_codex":[0.9999242,0.00001457318,0.000005257245,0.00001856615,0.00002248391,0.0000149049],"domain_scores_gemma":[0.9999366,0.00001202506,0.00002202963,0.000003594057,0.00000938522,0.00001638103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003544344,0.000004821689,0.00001643312,0.0000229564,0.0000014346,0.00002955539,0.000007924689,0.00004588127,0.9983684,0.0001633782,0.00002595832,0.001277754],"study_design_scores_gemma":[0.00001323217,0.00006378423,0.0001088149,0.000002117937,0.000003577403,0.00008010045,0.000004121132,0.0005135932,0.9973362,0.00004865813,0.001821331,0.00000449057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9389632,0.003015019,0.0524294,0.0004448918,0.0001311646,0.0001534624,0.0002439174,0.0004956673,0.004123246],"genre_scores_gemma":[0.9801465,0.00116374,0.01437288,0.0001313097,0.00001773329,0.00007331945,0.0001106944,0.00004737969,0.003936452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000903263,"threshold_uncertainty_score":0.003021657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047941561418179,"score_gpt":0.2410368024011219,"score_spread":0.2305573867869401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}