{"id":"W2550293882","doi":"10.1039/c6nr06701h","title":"Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery","year":2016,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Cationic polymerization; Endosome; Protonation; Molecular switch; Gene knockdown; Biophysics; Gene delivery; Chemistry; In vivo; Ionic bonding; Drug delivery; Nanotechnology; Combinatorial chemistry; Materials science; Molecule; Biochemistry; Gene; Transfection; Cell; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233901,0.0001779054,0.000159971,0.00004883942,0.00009119667,0.00002580697,0.0002780698,0.0002032304,0.00006925273],"category_scores_gemma":[0.0000936107,0.0001361635,0.0001729852,0.00007483556,0.00005109165,0.000009803412,0.00008014941,0.00004087075,0.0001182321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002917799,"about_ca_system_score_gemma":0.0001221912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002743369,"about_ca_topic_score_gemma":0.00004266912,"domain_scores_codex":[0.9988167,0.00002789012,0.0002310349,0.000443282,0.0001269911,0.0003540596],"domain_scores_gemma":[0.9991115,0.0000262764,0.00008099223,0.0004613681,0.0002235114,0.00009630778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112493,0.00005398097,0.0005320719,0.00001262758,0.00004832207,0.000001432787,0.00001236877,0.000005009694,0.9732208,0.0001002673,0.01407761,0.01182306],"study_design_scores_gemma":[0.0009088765,0.0003690426,0.0002385137,0.00003141819,0.00002333986,0.000006632113,0.00001901617,0.00002206299,0.902306,0.0004259759,0.09541699,0.000232102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776927,0.001130617,0.01854985,0.0006011148,0.0003763331,0.0003326672,0.00006100053,0.00002710312,0.001228673],"genre_scores_gemma":[0.9896554,0.0004045534,0.0006055736,0.0005429833,0.0003251486,0.0001228785,0.00006588223,0.00003301002,0.008244605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08133938,"threshold_uncertainty_score":0.5552585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047941561418179,"score_gpt":0.2410368024011219,"score_spread":0.2305573867869401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}