{"id":"W2550348382","doi":"10.1182/blood.v106.11.2605.2605","title":"Stable Suppression of a Novel Oncogene, AHI-1, in Human Cutaneous T-Cell Leukemia Cells Normalizes Its Transforming Activity In Vitro and In Vivo and Aberrant Expression of AHI-1 Is Also Present in Leukemic Sezary Cells from Patients with Sezary Syndrome.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Biology; Autocrine signalling; Cell culture; Leukemia; Provirus; Gene knockdown; Molecular biology; RNA interference; Small hairpin RNA; Cancer research; Immunology; Gene; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290849,0.0004481182,0.0002588412,0.0003034955,0.0001728085,0.0003235534,0.0001717233,0.0001931115,0.001976491],"category_scores_gemma":[0.0001152132,0.0001373193,0.0002282489,0.0002247474,0.0002333836,0.00009833777,0.0001280392,0.0005885434,0.0004449367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441336,"about_ca_system_score_gemma":0.0001838228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677782,"about_ca_topic_score_gemma":0.0009214033,"domain_scores_codex":[0.9998553,0.00001977555,0.00001684953,0.00003963646,0.00004089201,0.00002764391],"domain_scores_gemma":[0.9998724,0.00003004828,0.00003717218,0.00002313982,0.000009819043,0.0000273558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001721811,0.00001532319,0.00006162804,0.000005945712,0.000001504621,0.00001434347,0.000004816602,0.00001779148,0.9994991,0.00002134277,0.000009866882,0.0003310572],"study_design_scores_gemma":[0.000008891924,0.0002481526,0.001411916,0.000001894569,0.00001101443,0.0001649075,0.00001278368,0.0004844533,0.9968638,0.00000868649,0.0007815579,0.000001770175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942667,0.0005724411,0.003182093,0.00003735155,0.00002845662,0.0000616895,0.0005642952,0.000138129,0.001148867],"genre_scores_gemma":[0.9927744,0.0003867069,0.002919293,0.00001817744,0.000008374492,0.00005433597,0.001009659,0.00003656073,0.002792554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001976491,"threshold_uncertainty_score":0.006612003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005937374710615574,"score_gpt":0.2053744587937163,"score_spread":0.1994370840831008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}