{"id":"W2550348382","doi":"10.1182/blood.v106.11.2605.2605","title":"Stable Suppression of a Novel Oncogene, AHI-1, in Human Cutaneous T-Cell Leukemia Cells Normalizes Its Transforming Activity In Vitro and In Vivo and Aberrant Expression of AHI-1 Is Also Present in Leukemic Sezary Cells from Patients with Sezary Syndrome.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Biology; Autocrine signalling; Cell culture; Leukemia; Provirus; Gene knockdown; Molecular biology; RNA interference; Small hairpin RNA; Cancer research; Immunology; Gene; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214864,0.0002153394,0.0003513126,0.0001762787,0.00002469966,0.000008967221,0.0001174455,0.0002198599,0.00001313879],"category_scores_gemma":[0.000005837943,0.0001965877,0.00003236547,0.0001333097,0.00005649667,0.00004509119,0.00009972955,0.0001669004,1.175288e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005429574,"about_ca_system_score_gemma":0.0000922564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009879487,"about_ca_topic_score_gemma":0.0006795016,"domain_scores_codex":[0.9986064,0.00007383959,0.0004453706,0.0004136292,0.0002019098,0.0002588126],"domain_scores_gemma":[0.999506,0.00002592507,0.0001713171,0.0002047631,0.00002544269,0.00006653932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006546628,0.001132628,0.008235828,0.0001403125,0.000008629983,0.00001380461,0.0003811591,0.0003173285,0.9886828,8.954001e-8,0.00002202228,0.0004107444],"study_design_scores_gemma":[0.007248095,0.0002475333,0.003038915,0.0003653793,0.00001310174,0.000006686483,0.00006225728,0.0005401354,0.9881557,0.000001678917,0.0001063421,0.0002141358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983332,0.0007122575,0.00001836594,0.000008561969,0.0000193826,0.0005680945,0.0002233925,0.00000350735,0.0001132303],"genre_scores_gemma":[0.9989137,0.0003445103,0.0005485747,0.00001853893,0.00001357787,0.00002410643,0.00005599783,0.00002136927,0.00005959843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006593432,"threshold_uncertainty_score":0.8016613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005937374710615574,"score_gpt":0.2053744587937163,"score_spread":0.1994370840831008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}