{"id":"W2550403115","doi":"10.1182/blood.v110.11.467.467","title":"Interaction of a Novel Signaling Protein (AHI-1) with BCR-ABL Modulates BCR-ABL Transforming Activity and Imatinib Response of Chronic Myeloid Leukemia Progenitor Cells.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Biology; Myeloid leukemia; K562 cells; Cancer research; Progenitor cell; ABL; Gene knockdown; Imatinib mesylate; breakpoint cluster region; Leukemia; Ectopic expression; Stem cell; Fusion protein; Molecular biology; Cell culture; Signal transduction; Tyrosine kinase; Immunology; Cell biology; Imatinib; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145528,0.0002626817,0.0002061839,0.0001444371,0.0001500639,0.0002365371,0.0001529238,0.0002141685,0.0007455578],"category_scores_gemma":[0.0000772894,0.00009658898,0.0001823456,0.0001545363,0.0001625266,0.0001142812,0.000149022,0.0003910713,0.000254735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002907967,"about_ca_system_score_gemma":0.0001234579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002424632,"about_ca_topic_score_gemma":0.0003931595,"domain_scores_codex":[0.9998417,0.00002753099,0.0000126447,0.00002656355,0.00004533663,0.0000462996],"domain_scores_gemma":[0.9999524,0.0000109786,0.00001451905,0.000004300579,0.000003927671,0.00001381765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004272219,0.00002174335,0.0001054081,0.00001386061,0.000002020379,0.00001508791,0.000005923528,0.00002852857,0.9994251,0.00003603069,0.00001295057,0.000290709],"study_design_scores_gemma":[0.00001755034,0.0003007225,0.004549286,0.000003166579,0.00001200543,0.0001276665,0.00001830056,0.0009966792,0.992627,0.00002171362,0.001323012,0.000003065947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975588,0.0007600133,0.000708909,0.00004684827,0.00001417586,0.00002852781,0.0002755453,0.00002249971,0.0005846963],"genre_scores_gemma":[0.9975648,0.0003944963,0.0007295934,0.0000226257,0.000006055352,0.00003497262,0.0004656182,0.000005303887,0.0007765744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007455578,"threshold_uncertainty_score":0.002494156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346399411720146,"score_gpt":0.2577987692993114,"score_spread":0.24433477518211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}