{"id":"W2550419061","doi":"10.1007/s40259-016-0204-3","title":"Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitors","year":2016,"lang":"en","type":"review","venue":"BioDrugs","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Ontario Institute for Cancer Research","keywords":"Immune system; Immunology; Medicine; Adverse effect; Autoimmunity; Immunotherapy; Antibody; Immune checkpoint; Cytotoxic T cell; CTLA-4; Nivolumab; T cell; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000787278,0.0008202319,0.002508029,0.0003630065,0.000130507,0.00001127893,0.0003057439,0.0008357855,0.0009379983],"category_scores_gemma":[0.0001225724,0.0004758021,0.001809522,0.0008329203,0.0002341152,0.00009572685,0.00009680582,0.0005966078,0.0006209209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026994,"about_ca_system_score_gemma":0.0009373314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001009704,"about_ca_topic_score_gemma":0.000005051386,"domain_scores_codex":[0.9962163,0.0002093725,0.001720878,0.0006617326,0.0005659453,0.0006257722],"domain_scores_gemma":[0.9973187,0.0001279167,0.001355601,0.0008737987,0.0001421879,0.0001817677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006907583,0.000398227,0.00006134583,0.004492113,0.005795133,0.000127913,0.0001450078,1.58079e-8,0.0003118791,0.000007504169,0.0009730743,0.986997],"study_design_scores_gemma":[0.004549214,0.0003779545,0.0004614578,0.09405254,0.001718815,0.0001370496,0.00003061095,2.443073e-7,0.0001566562,0.000004643272,0.8978357,0.0006751343],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005458122,0.994088,0.000001615656,0.0001802305,0.00101807,0.001762855,0.0001527008,0.0002286582,0.002022059],"genre_scores_gemma":[0.0004172738,0.9841294,0.00002358003,0.00005259792,0.000182271,0.0001399863,0.0006527184,0.000168749,0.01423347],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9863219,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959998934634755,"score_gpt":0.2869797453921792,"score_spread":0.2673797560458316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}