{"id":"W2550491072","doi":"10.1039/c6ra19197e","title":"Mechanistic study of allopurinol oxidation using aldehyde oxidase, xanthine oxidase and cytochrome P450 enzymes","year":2016,"lang":"en","type":"article","venue":"RSC Advances","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Kermanshah University of Medical Sciences; University of British Columbia; Razi University","keywords":"Allopurinol; Xanthine oxidase; Aldehyde oxidase; Chemistry; Enzyme; Cytochrome P450; Metabolite; Xanthine oxidase inhibitor; Biochemistry; Oxidase test; Stereochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003461954,0.0004047798,0.000190004,0.0002556737,0.0002534082,0.00027415,0.0003601784,0.000412322,0.0009377398],"category_scores_gemma":[0.0001486059,0.0001232047,0.0003717515,0.0001695769,0.0002511161,0.0006342488,0.0001766702,0.0004547345,0.0001995525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973563,"about_ca_system_score_gemma":0.0001711673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005025474,"about_ca_topic_score_gemma":0.0004954604,"domain_scores_codex":[0.9998734,0.000038814,0.000004908016,0.00002264679,0.00003403131,0.00002618466],"domain_scores_gemma":[0.9999309,0.00001127393,0.00001927122,0.000008452954,0.0000193819,0.00001070783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004415233,0.0001991977,0.00276668,0.000590265,0.00008925996,0.0009274166,0.0001162268,0.001047732,0.9622466,0.008428421,0.0002677287,0.02287906],"study_design_scores_gemma":[0.00002696836,0.0008474712,0.006361465,0.00002944871,0.00007199343,0.001272749,0.0001499036,0.002748039,0.9715979,0.002502518,0.01437092,0.00002058781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8862005,0.05188652,0.04314223,0.00185271,0.0002778446,0.000176449,0.0003133606,0.0001167781,0.01603363],"genre_scores_gemma":[0.9821723,0.00941312,0.004914702,0.0001283032,0.00005396347,0.00002589998,0.0001322801,0.000003848213,0.003155584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009377398,"threshold_uncertainty_score":0.003136992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315311066032895,"score_gpt":0.2717514087327774,"score_spread":0.2585982980724485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}