{"id":"W2550627817","doi":"10.1182/blood.v116.21.2278.2278","title":"Presence of Prior-to-Treatment BCR-ABL Mutations In CD34+CD38- Stem Cells of Newly Diagnosed Chronic Phase CML Patients and Their Correlation with Imatinib Resistance: Implications of Cancer Pharmacogenomics and Pre-Therapeutic Genetic Testing In Personalized Treatment of BCR-ABL+ Leukemia","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Imatinib; CD38; Medicine; Imatinib mesylate; Internal medicine; Oncology; Cancer research; CD34; Population; Immunology; Gastroenterology; Myeloid leukemia; Stem cell; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199437,0.0002112685,0.0005420951,0.0002192582,0.00003877811,0.000006464975,0.00009054814,0.00007937046,0.00001396529],"category_scores_gemma":[0.00004843533,0.0001633248,0.00004276984,0.0004665282,0.0002684761,0.00005832857,0.00002973971,0.00009053489,2.285264e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002249122,"about_ca_system_score_gemma":0.004022934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002772152,"about_ca_topic_score_gemma":0.002729245,"domain_scores_codex":[0.9984551,0.00007677735,0.0006443039,0.0003421241,0.0002276074,0.0002540791],"domain_scores_gemma":[0.998198,0.0006963937,0.0003964939,0.0003284894,0.0002636569,0.0001169784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001413534,0.004716795,0.3047769,0.0009792364,0.0003805715,0.00001045617,0.01414357,0.002102304,0.6021249,0.00002122708,0.000001872139,0.06932861],"study_design_scores_gemma":[0.1622985,0.00426588,0.3210802,0.001003887,0.0007716925,0.00001920036,0.0006301009,0.02568026,0.4839066,0.00004303605,0.00004171444,0.0002589933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994207,0.002907958,0.00005705592,0.00002986672,0.00001866866,0.002516403,0.000223608,0.00000784696,0.00003161881],"genre_scores_gemma":[0.9964516,0.000802411,0.002223941,0.00000509277,0.00001607065,0.0003819076,0.00002383408,0.00002802909,0.00006712346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1608849,"threshold_uncertainty_score":0.7136512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229926284810166,"score_gpt":0.3169263500059408,"score_spread":0.2946270871578391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}