{"id":"W2550627817","doi":"10.1182/blood.v116.21.2278.2278","title":"Presence of Prior-to-Treatment BCR-ABL Mutations In CD34+CD38- Stem Cells of Newly Diagnosed Chronic Phase CML Patients and Their Correlation with Imatinib Resistance: Implications of Cancer Pharmacogenomics and Pre-Therapeutic Genetic Testing In Personalized Treatment of BCR-ABL+ Leukemia","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Imatinib; CD38; Medicine; Imatinib mesylate; Internal medicine; Oncology; Cancer research; CD34; Population; Immunology; Gastroenterology; Myeloid leukemia; Stem cell; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601208,0.0001950691,0.0002014731,0.0008558386,0.0002076111,0.0002753985,0.0001637524,0.0003619277,0.00170923],"category_scores_gemma":[0.0008204252,0.0001485932,0.00009381521,0.0004145522,0.0002064093,0.0001766688,0.0001592561,0.0002521047,0.0002090893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001277846,"about_ca_system_score_gemma":0.00009602968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004157521,"about_ca_topic_score_gemma":0.0005175343,"domain_scores_codex":[0.9998216,0.00002554891,0.00002236367,0.00004917566,0.00004698052,0.00003427557],"domain_scores_gemma":[0.9994507,0.0001761493,0.000181878,0.00002786765,0.00005115581,0.0001122167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006739243,0.00009264847,0.9692668,0.00003075329,0.00002175716,0.001179588,0.0001804908,0.00005884015,0.02342802,0.00002429792,0.00006930314,0.004973547],"study_design_scores_gemma":[0.00001528539,0.0003526955,0.992366,0.000002946107,0.00001598187,0.004319799,0.0001293847,0.0001699165,0.002305458,0.00001783073,0.0003011241,0.000003572116],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999653,0.0001390549,0.0000379101,0.000007787275,0.000001119149,0.00000508195,0.00004790302,0.000001303818,0.0001069027],"genre_scores_gemma":[0.9995992,0.00007212534,0.00009803977,0.000009051744,0.00000580593,0.000006203068,0.0001207925,9.001724e-7,0.00008791347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170923,"threshold_uncertainty_score":0.005717933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229926284810166,"score_gpt":0.3169263500059408,"score_spread":0.2946270871578391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}