{"id":"W2550646651","doi":"10.1158/1078-0432.ccr-16-1700","title":"TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Lawson Health Research Institute; Western University; Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Phagocytosis; Cancer research; Macrophage; Immune system; Innate immune system; In vivo; Flow cytometry; Immunology; Antibody; Biology; Cancer cell; Cancer; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00293906,0.0002458008,0.0006091797,0.0002334044,0.0005192311,0.00006661817,0.0003059488,0.000364698,0.0003812636],"category_scores_gemma":[0.0005810641,0.0001547426,0.000143674,0.0003840737,0.001551009,0.000359768,0.0004816251,0.0009497043,0.0001689493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001972411,"about_ca_system_score_gemma":0.0003876579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004272999,"about_ca_topic_score_gemma":0.0001343492,"domain_scores_codex":[0.9966857,0.0008373263,0.0006690789,0.0007519457,0.000193507,0.0008624305],"domain_scores_gemma":[0.9978792,0.0009914944,0.0002454462,0.0004799153,0.0003118782,0.00009207222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002463367,0.0001997739,0.02587646,0.00004662083,0.0001932516,0.00001226342,0.00009337801,2.79515e-7,0.896908,0.00007298716,0.0004720088,0.07366162],"study_design_scores_gemma":[0.005228966,0.001136531,0.305684,0.0007459715,0.00003517206,0.00004291781,0.00008430826,0.00001008249,0.6739209,0.00005200911,0.01274405,0.0003150451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991501,0.005123443,0.00005127674,0.00201892,0.0004774914,0.0004489156,0.00004228433,0.00005860542,0.000278023],"genre_scores_gemma":[0.9945081,0.00245909,0.00004602784,0.00002927212,0.0002230991,0.00009445111,0.000009184902,0.00003840168,0.002592404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2798076,"threshold_uncertainty_score":0.6310221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1095507293000754,"score_gpt":0.4224291831128441,"score_spread":0.3128784538127687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}