{"id":"W2550804007","doi":"10.1182/blood.v124.21.4529.4529","title":"MiR-300 Acts As a Tumor Supressor in Ph+ Progenitors By Modulating the JAK2-SET/PP2A/β-Catenin Interplay","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Chronic myelogenous leukemia; Biology; Cancer research; Progenitor cell; Haematopoiesis; Stem cell; CD38; Leukemia; breakpoint cluster region; Tyrosine kinase; Protein phosphatase 2; Imatinib mesylate; Immunology; Cell biology; Imatinib; Signal transduction; CD34; Myeloid leukemia; Genetics; Phosphatase; Receptor; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006983846,0.0001794617,0.0001812034,0.000156158,0.0001169696,0.0002547911,0.0001111317,0.0001415662,0.001181038],"category_scores_gemma":[0.0001189855,0.0001170938,0.0001580472,0.00007245381,0.0001259401,0.0001029041,0.0001553822,0.0002479777,0.0003893544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165159,"about_ca_system_score_gemma":0.00009527944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001731415,"about_ca_topic_score_gemma":0.0003140692,"domain_scores_codex":[0.9999335,0.00000891218,0.00000509293,0.00001903406,0.00002224592,0.00001119337],"domain_scores_gemma":[0.9999611,0.00000797463,0.00001123032,0.000003727709,0.000004640851,0.00001130183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001189694,0.00001117254,0.0002485068,0.00002076844,0.000004243365,0.00003583443,0.000005987605,0.00006645519,0.9983779,0.00005560106,0.00003677369,0.00101772],"study_design_scores_gemma":[0.00001959639,0.0002008477,0.009764153,0.000005650998,0.00002329287,0.0003345691,0.00002656539,0.002790841,0.9841706,0.0001149718,0.002543001,0.000005815408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929668,0.001220749,0.00297747,0.00007076077,0.00002984197,0.00002660134,0.0003882967,0.0001678676,0.002151631],"genre_scores_gemma":[0.9973128,0.0002335074,0.001145988,0.00003718073,0.000004196529,0.00001526769,0.0003196819,0.0000179401,0.0009134129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181038,"threshold_uncertainty_score":0.003950953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031245544273379,"score_gpt":0.2688393094466123,"score_spread":0.2585268540038785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}