{"id":"W2550819725","doi":"10.1136/annrheumdis-2016-eular.2021","title":"THU0138 Secondary Efficacy Results Up To Week 24 from A Phase III Study Comparing SB5 (An Adalimumab Biosimiar) with Adalimumab Reference Product in Patients with Moderate To Severe Rheumatoid Arthritis despite Methotrexate Therapy","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Medicine; Adalimumab; Rheumatoid arthritis; Clinical endpoint; Internal medicine; Methotrexate; Surrogate endpoint; Physical therapy; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000558107,0.000512401,0.001116632,0.0001968092,0.0002211074,0.00006672202,0.0007931,0.0001055501,0.000187485],"category_scores_gemma":[0.0004180803,0.0002538307,0.0001208068,0.000501338,0.0002676781,0.0002901163,0.0002534824,0.0002513251,0.00002509324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003172949,"about_ca_system_score_gemma":0.0001756231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005743366,"about_ca_topic_score_gemma":0.0004382028,"domain_scores_codex":[0.9959779,0.001267357,0.0009539166,0.00091336,0.0002519093,0.0006355821],"domain_scores_gemma":[0.9971434,0.0006031757,0.0004311342,0.001286321,0.0003299729,0.0002060247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1965766,0.02143465,0.05529324,0.0001045065,0.003817936,0.00001875001,0.0107894,0.0003005986,0.003333698,0.00010282,0.005280739,0.7029471],"study_design_scores_gemma":[0.1237587,0.01657776,0.8007909,0.008073902,0.000266337,0.00001004574,0.002414747,0.00005469154,0.04412666,0.0008737465,0.001146188,0.001906384],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932134,0.001388437,0.0001246703,0.001595136,0.000182968,0.002039138,0.001340416,0.0000635755,0.00005226473],"genre_scores_gemma":[0.9980449,0.0003502832,0.0006046888,0.0006226479,0.000008825077,0.0001014665,0.00006759571,0.00004533805,0.0001542591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7454976,"threshold_uncertainty_score":0.9999914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06699277095954076,"score_gpt":0.3212752334356977,"score_spread":0.2542824624761569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}