{"id":"W2550819759","doi":"10.1128/msphere.00288-16","title":"A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression","year":2016,"lang":"en","type":"article","venue":"mSphere","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Child Health and Human Development; Government of Canada","keywords":"Residue (chemistry); Human immunodeficiency virus (HIV); Biology; Valine; Alanine; Strain (injury); Genetics; Function (biology); Cell biology; Virology; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004369,0.0001117549,0.0001106944,0.00009369486,0.0001020432,0.0001725026,0.0001298092,0.0001640992,0.000474003],"category_scores_gemma":[0.0001579513,0.00006051835,0.0000681317,0.00009011808,0.0001361985,0.00009373026,0.00009373741,0.0001816999,0.0001769927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001458617,"about_ca_system_score_gemma":0.00007848218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003473804,"about_ca_topic_score_gemma":0.000490061,"domain_scores_codex":[0.9999226,0.00002265654,0.000005060712,0.00001449197,0.00001653408,0.00001865483],"domain_scores_gemma":[0.9999444,0.00001584805,0.00001464352,0.000006782095,0.000005994741,0.00001233316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007640602,0.00001034534,0.0004493236,0.000005707904,0.000001084063,0.00002102004,0.000006267961,0.00002119538,0.9987109,0.00001506706,0.00000858782,0.0006740548],"study_design_scores_gemma":[0.00002403861,0.0005415343,0.05442424,0.000008924866,0.00001226916,0.0003719619,0.00006145878,0.0009961555,0.9421583,0.00009731172,0.001297057,0.000006800184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999097,0.0002543213,0.0002419647,0.00001391474,0.000002172871,0.000003012428,0.00003985906,0.000005429868,0.0003423867],"genre_scores_gemma":[0.9990596,0.0001335146,0.0004496897,0.00001486655,0.000001803879,0.000003353818,0.00008437366,0.000003314353,0.0002495381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000474003,"threshold_uncertainty_score":0.001585722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257007299673388,"score_gpt":0.2368448341232347,"score_spread":0.2242747611265009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}