{"id":"W2550865537","doi":"10.1161/circgenetics.116.001572","title":"Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis","year":2016,"lang":"en","type":"review","venue":"Circulation Cardiovascular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Queensland Brain Institute; Graduate School of Public Health, University of Pittsburgh; University of North Carolina at Chapel Hill; Hjartavernd; Tays; Turun Yliopisto; Háskóli Íslands; Universitair Medisch Centrum Groningen; National Center for Advancing Translational Sciences; Medical Research Council; Leids Universitair Medisch Centrum; Rijksuniversiteit Groningen; Erasmus Medisch Centrum; Cedars-Sinai Medical Center; Netherlands Heart Institute; Imperial College London; Deutsches Zentrum für Herz-Kreislaufforschung; University of Texas Health Science Center at Houston; School of Public Health, University of Michigan; Broad Institute; U.S. Department of Veterans Affairs; Harvard T.H. Chan School of Public Health; National Institutes of Health; Regeneron Pharmaceuticals; Kanazawa University; University of Pittsburgh; NIH Clinical Center; Universiteit Maastricht; Johns Hopkins University; University of Washington; Massachusetts General Hospital; University of Minnesota; Turun Yliopistollinen Keskussairaala; University of Vermont; Vanderbilt University; Tampereen Yliopisto; University of Pennsylvania; Perelman School of Medicine, University of Pennsylvania; Universiteit Leiden","keywords":"Medicine; Asymptomatic; Subclinical infection; Internal medicine; Intima-media thickness; Apolipoprotein E; Odds ratio; Coronary atherosclerosis; Exome sequencing; Coronary artery disease; Cardiology; Genome-wide association study; Single-nucleotide polymorphism; Disease; Genetics; Genotype; Biology; Mutation; Carotid arteries","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00231434,0.0005369293,0.00235922,0.0001663409,0.0001183682,0.00002150934,0.0004641703,0.001326013,0.000019459],"category_scores_gemma":[0.001781583,0.0004719741,0.002805083,0.0003117248,0.00006368641,0.000003782042,0.0002466202,0.000255878,0.00006053866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299108,"about_ca_system_score_gemma":0.0002632067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001225332,"about_ca_topic_score_gemma":0.00002067473,"domain_scores_codex":[0.9944796,0.001782865,0.001631792,0.000987704,0.0006387487,0.0004793219],"domain_scores_gemma":[0.9959903,0.0004783852,0.001266211,0.001680407,0.0004512673,0.0001334767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001067609,0.0006498926,0.2822187,0.001583703,0.01575764,0.000002191564,0.000120442,0.002257615,0.00005723482,0.000002395751,0.001661881,0.6956776],"study_design_scores_gemma":[0.001285638,0.0003134165,0.07840226,0.0005645022,0.003519314,0.00000383158,0.00005221053,0.00001483996,0.000007187809,0.00001978048,0.9151382,0.0006788018],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02431736,0.9690996,0.004173725,0.00001056824,0.000642647,0.00156056,0.00007824782,0.00002310623,0.00009419397],"genre_scores_gemma":[0.03169178,0.9663809,0.0003802828,0.00002992059,0.000614701,0.0002052519,0.0003161991,0.0001221824,0.0002587766],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9134763,"threshold_uncertainty_score":0.9999705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07060995604317968,"score_gpt":0.3360230341585809,"score_spread":0.2654130781154013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}