{"id":"W2550865537","doi":"10.1161/circgenetics.116.001572","title":"Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis","year":2016,"lang":"en","type":"review","venue":"Circulation Cardiovascular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Queensland Brain Institute; Graduate School of Public Health, University of Pittsburgh; University of North Carolina at Chapel Hill; Hjartavernd; Tays; Turun Yliopisto; Háskóli Íslands; Universitair Medisch Centrum Groningen; National Center for Advancing Translational Sciences; Medical Research Council; Leids Universitair Medisch Centrum; Rijksuniversiteit Groningen; Erasmus Medisch Centrum; Cedars-Sinai Medical Center; Netherlands Heart Institute; Imperial College London; Deutsches Zentrum für Herz-Kreislaufforschung; University of Texas Health Science Center at Houston; School of Public Health, University of Michigan; Broad Institute; U.S. Department of Veterans Affairs; Harvard T.H. Chan School of Public Health; National Institutes of Health; Regeneron Pharmaceuticals; Kanazawa University; University of Pittsburgh; NIH Clinical Center; Universiteit Maastricht; Johns Hopkins University; University of Washington; Massachusetts General Hospital; University of Minnesota; Turun Yliopistollinen Keskussairaala; University of Vermont; Vanderbilt University; Tampereen Yliopisto; University of Pennsylvania; Perelman School of Medicine, University of Pennsylvania; Universiteit Leiden","keywords":"Medicine; Asymptomatic; Subclinical infection; Internal medicine; Intima-media thickness; Apolipoprotein E; Odds ratio; Coronary atherosclerosis; Exome sequencing; Coronary artery disease; Cardiology; Genome-wide association study; Single-nucleotide polymorphism; Disease; Genetics; Genotype; Biology; Mutation; Carotid arteries","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001828578,0.0006047146,0.001058717,0.0009471989,0.0006107081,0.0009796984,0.0005089141,0.0008443065,0.002417136],"category_scores_gemma":[0.003562899,0.0002843886,0.00169068,0.002473539,0.0002414521,0.0003251071,0.0009756901,0.0008126562,0.000210398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517269,"about_ca_system_score_gemma":0.0003185266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002889458,"about_ca_topic_score_gemma":0.003703139,"domain_scores_codex":[0.9986266,0.0005901746,0.0001433137,0.0004094473,0.0001432667,0.00008732164],"domain_scores_gemma":[0.9980519,0.0007011658,0.0005043196,0.0003752291,0.0002238398,0.000143602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00248711,0.0001140054,0.9301729,0.001016055,0.03702246,0.0009802275,0.0003590664,0.001027939,0.008510434,0.0005171365,0.003389857,0.01440288],"study_design_scores_gemma":[0.0001623533,0.0001203847,0.9860298,0.0001064068,0.00844622,0.0006553979,0.0001186995,0.0006290919,0.0004381286,0.0005869213,0.002684323,0.00002223174],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9619844,0.02361446,0.003071789,0.001106792,0.0001495862,0.00004756058,0.008431223,0.00005536251,0.001538865],"genre_scores_gemma":[0.991141,0.003575986,0.0009788699,0.0003082482,0.00005705882,0.00007878826,0.003429014,0.00001591681,0.0004150805],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002889458,"threshold_uncertainty_score":0.009670556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07060995604317968,"score_gpt":0.3360230341585809,"score_spread":0.2654130781154013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}