{"id":"W2550953164","doi":"10.1016/j.jviromet.2016.11.004","title":"In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach","year":2016,"lang":"en","type":"article","venue":"Journal of Virological Methods","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Global Affairs Canada; National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; International Development Research Centre","keywords":"Biology; Genetics; Primer (cosmetics); Virology; Coding region; Function (biology); Gene; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001729303,0.0001201979,0.0004118426,0.0002101465,0.00005930792,0.000005517955,0.0001790593,0.000166911,0.0002810725],"category_scores_gemma":[0.0002612568,0.00006061954,0.0001637637,0.0001322523,0.0003144856,0.0001789336,0.00007766763,0.000434616,0.000005366232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196138,"about_ca_system_score_gemma":0.0001240342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001034267,"about_ca_topic_score_gemma":4.424516e-7,"domain_scores_codex":[0.9974478,0.001584962,0.0004288269,0.0001602661,0.00009611698,0.0002819871],"domain_scores_gemma":[0.9985831,0.0008956488,0.0003071245,0.00008916217,0.00008435795,0.00004061082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009488825,0.0003594203,0.005191903,0.000007013903,0.0001812693,0.00005859706,0.00003400669,0.00002946036,0.9778455,0.0005013545,0.00003529288,0.01480731],"study_design_scores_gemma":[0.02019124,0.005898781,0.5166655,0.0002267011,0.0003577445,0.00374835,0.001035443,0.0007559245,0.4383186,0.004868125,0.007288113,0.0006454259],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8168452,0.001038289,0.1809903,0.0004019401,0.000325668,0.00009777878,0.0000137537,0.000004974627,0.000282069],"genre_scores_gemma":[0.7773,0.00004672906,0.2224882,0.00003208076,0.00003620741,0.000001876332,0.000003842047,0.00000355145,0.00008744928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5395269,"threshold_uncertainty_score":0.3077546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08047869836539208,"score_gpt":0.3962553536116585,"score_spread":0.3157766552462664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}