{"id":"W2551013397","doi":"10.1182/blood.v126.23.4422.4422","title":"In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Zinc finger nuclease; Homology (biology); Genome editing; Homology directed repair; Biology; Gene; Zinc finger; In vivo; Molecular biology; DNA; Nuclease; Cell biology; Genome; DNA repair; Genetics; Nucleotide excision repair; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005045288,0.0003176341,0.0003945043,0.0002753951,0.00008683494,0.0002862839,0.0003061584,0.0004047887,0.002000167],"category_scores_gemma":[0.000202281,0.0001637004,0.00023333,0.00009904018,0.0003538194,0.0002238855,0.0002221565,0.0008582792,0.0005296955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002274822,"about_ca_system_score_gemma":0.000180538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003761312,"about_ca_topic_score_gemma":0.000702651,"domain_scores_codex":[0.9995807,0.00009079991,0.00003884877,0.0001071504,0.0001133706,0.00006919917],"domain_scores_gemma":[0.9997242,0.00005513918,0.00008492505,0.00003892118,0.00002296705,0.0000737243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005972355,0.00002650808,0.000090762,0.00001786242,0.000002181544,0.00002506108,0.000009387346,0.00002206011,0.9992452,0.00004850307,0.00001361543,0.0004392839],"study_design_scores_gemma":[0.0000142078,0.0007230248,0.001831325,0.000006070587,0.000009270197,0.0002236213,0.00001797443,0.0003249686,0.9957833,0.00002343691,0.001039624,0.000003103522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894491,0.0009530699,0.0072605,0.00008959666,0.00003680288,0.0001041399,0.0002681001,0.0001580015,0.001680644],"genre_scores_gemma":[0.98835,0.0005778372,0.00599747,0.00009168338,0.00001336686,0.0001092936,0.0004909321,0.00003969556,0.004329834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002000167,"threshold_uncertainty_score":0.006691158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080893698961527,"score_gpt":0.2542070559458054,"score_spread":0.2433981189561901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}