{"id":"W2551184473","doi":"10.1136/annrheumdis-2016-eular.1846","title":"THU0174 A Safety Analysis of Tofacitinib 5 mg Twice Daily Administered as Monotherapy or in Combination with Background Conventional Synthetic Dmards in A Phase 3 Rheumatoid Arthritis Population","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Medicine; Tofacitinib; Adverse effect; Rheumatoid arthritis; Internal medicine; Combination therapy; Methotrexate; Population; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002938198,0.0008617574,0.00132957,0.0006754317,0.0004791038,0.001247952,0.0008416445,0.001128613,0.005725386],"category_scores_gemma":[0.002810324,0.000412783,0.002718558,0.000580974,0.0006849624,0.0008098331,0.0003548343,0.002537222,0.0009765313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001068712,"about_ca_system_score_gemma":0.001683622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047362,"about_ca_topic_score_gemma":0.001556288,"domain_scores_codex":[0.9984652,0.0008528538,0.00006943843,0.0002157468,0.0002420535,0.0001547643],"domain_scores_gemma":[0.9987444,0.0003863855,0.0003039305,0.0001083225,0.0001909835,0.0002659059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7762107,0.009287397,0.02373595,0.001011186,0.006030563,0.0006847574,0.0001829598,0.001802985,0.03687969,0.000547572,0.008985632,0.1346406],"study_design_scores_gemma":[0.437636,0.4420697,0.07361179,0.0002897996,0.01016378,0.002538561,0.0003209869,0.004449145,0.01044029,0.001001645,0.01734571,0.0001327105],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854949,0.004609007,0.0006980567,0.0007152283,0.0002053011,0.0005743931,0.003121228,0.0001146671,0.004467196],"genre_scores_gemma":[0.9903036,0.001615457,0.0007328721,0.0007510578,0.000241459,0.0003562585,0.004032415,0.00003887719,0.001928008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005725386,"threshold_uncertainty_score":0.0191533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04997734749271165,"score_gpt":0.3691876380807219,"score_spread":0.3192102905880103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}