{"id":"W2551325974","doi":"10.1038/npjvaccines.2016.21","title":"In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine","year":2016,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; INOVIO Pharmaceuticals; Public Health Agency of Canada; University of Pennsylvania","keywords":"Zika virus; Virology; DNA vaccination; Biology; Immunology; Immune system; Immunity; Immunogen; Antibody; Virus; Interferon; Neutralizing antibody; Immunization; Medicine; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007013977,0.0002052439,0.000301037,0.0001193923,0.00009051024,0.00002148921,0.00002438526,0.00009885641,0.00007074427],"category_scores_gemma":[0.00004302582,0.0001245686,0.00004229253,0.0001935716,0.00001787972,0.000436568,0.00001490821,0.00007872643,0.000002038074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005960975,"about_ca_system_score_gemma":0.00005065888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002683312,"about_ca_topic_score_gemma":0.0003976502,"domain_scores_codex":[0.9990438,0.00006420792,0.0002130767,0.0003477927,0.0001318465,0.0001993011],"domain_scores_gemma":[0.9995205,0.00003945142,0.00006152596,0.0001817002,0.000121863,0.00007498672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003735041,0.0002347559,0.123102,0.000173611,0.0001272895,0.00002811609,0.0006643459,0.000002199577,0.7695408,0.00009869993,0.00004472636,0.1022484],"study_design_scores_gemma":[0.01063244,0.001305274,0.9282208,0.0004016245,0.0002327627,0.00005808926,0.0002521571,0.0001329115,0.05760693,0.0002008715,0.0007228799,0.0002332525],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936579,0.0002670114,0.002319487,0.002294141,0.00005744509,0.00119526,0.00001838995,0.00004962459,0.0001407263],"genre_scores_gemma":[0.9979519,0.001207302,0.00003765104,0.0002290185,0.0001604155,0.0002333817,0.00001059334,0.00002694429,0.0001428568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8051188,"threshold_uncertainty_score":0.5079761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007527500506667664,"score_gpt":0.247386181667978,"score_spread":0.2398586811613104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}