{"id":"W2551328408","doi":"10.1371/journal.pgen.1006414","title":"Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canton de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; DNA replication; Replication factor C; Minichromosome maintenance; Licensing factor; Cell biology; Origin of replication; Genetics; Control of chromosome duplication; Origin recognition complex; Eukaryotic DNA replication; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008315223,0.0005314129,0.0003408211,0.0001852678,0.0001448338,0.0003881033,0.000372583,0.0003097816,0.001563938],"category_scores_gemma":[0.0001046154,0.0001624068,0.000218059,0.0001055857,0.0001722185,0.0001359313,0.0003763886,0.0005226045,0.001323472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925826,"about_ca_system_score_gemma":0.0001671354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003967599,"about_ca_topic_score_gemma":0.0005188314,"domain_scores_codex":[0.9998733,0.00001441798,0.00001095821,0.00003471628,0.00004271112,0.00002392931],"domain_scores_gemma":[0.9998722,0.00001391625,0.00004620939,0.00001902351,0.00001504728,0.00003361131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005691491,0.000006467316,0.0001095387,0.000033874,0.000002427507,0.00002994946,0.000005061444,0.00004666621,0.9985251,0.00004801834,0.00004274095,0.001093271],"study_design_scores_gemma":[0.000008401825,0.00007791712,0.001803592,0.000005245223,0.000005102758,0.0001321285,0.00001037696,0.0004645541,0.9949875,0.000028852,0.002472142,0.000004132528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836087,0.007426232,0.00402644,0.0001600649,0.0000478921,0.00002455693,0.001255708,0.0006190659,0.002831443],"genre_scores_gemma":[0.9913648,0.001592978,0.002197662,0.00005349904,0.0000117882,0.00002204599,0.001159729,0.00008051471,0.003516904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563938,"threshold_uncertainty_score":0.005231917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629741579314379,"score_gpt":0.243337169731014,"score_spread":0.2270397539378702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}