{"id":"W2551328408","doi":"10.1371/journal.pgen.1006414","title":"Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Canton de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; DNA replication; Replication factor C; Minichromosome maintenance; Licensing factor; Cell biology; Origin of replication; Genetics; Control of chromosome duplication; Origin recognition complex; Eukaryotic DNA replication; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305005,0.000173391,0.0001507942,0.0000299056,0.00007197202,0.00002820773,0.0002395364,0.0001939057,0.00003249537],"category_scores_gemma":[0.0002820912,0.0001430147,0.00007540749,0.00005786475,0.0000568162,0.00000411407,0.0001563249,0.000090652,0.00005783414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003716148,"about_ca_system_score_gemma":0.00004436218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002228573,"about_ca_topic_score_gemma":0.000003412422,"domain_scores_codex":[0.9986374,0.00006498059,0.000270524,0.0005451529,0.0001747486,0.0003072164],"domain_scores_gemma":[0.998963,0.00001398181,0.0001365836,0.0006446741,0.0001281584,0.0001135915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000194558,0.00005353468,0.0003920954,0.000009215817,0.00003902557,8.491217e-7,0.00001936605,0.000001768723,0.994166,0.00008206158,0.0004270123,0.004789677],"study_design_scores_gemma":[0.0004858946,0.0001593396,0.0001064636,0.00002530499,0.00002422392,0.000008051012,0.00002536304,0.0001712704,0.9847049,0.0002167696,0.01385926,0.0002131742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988898,0.0007852177,0.008445689,0.0003001994,0.00007417908,0.0002831024,0.0001125539,0.00005356103,0.001047481],"genre_scores_gemma":[0.9960361,0.0001966389,0.002170041,0.0002480897,0.000289666,0.00005075662,0.00009520498,0.00004523081,0.0008682985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01343224,"threshold_uncertainty_score":0.5831972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629741579314379,"score_gpt":0.243337169731014,"score_spread":0.2270397539378702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}