{"id":"W2551339155","doi":"10.1038/srep37601","title":"Regulation of Anticancer Styrylpyrone Biosynthesis in the Medicinal Mushroom Inonotus obliquus Requires Thioredoxin Mediated Transnitrosylation of S-nitrosoglutathione Reductase","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Fungal Biology and Applications","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Genetics; Institute of Microbiology, Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Biosynthesis; Reductase; Thioredoxin; Thioredoxin reductase; Biochemistry; Inonotus obliquus; Nitric oxide; Phenylpropanoid; Chemistry; Polyphenol; Enzyme; Cell biology; Biology; Antioxidant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000596059,0.0002387895,0.0001493479,0.00007800489,0.00007692968,0.000167943,0.0001031963,0.0001135052,0.000329756],"category_scores_gemma":[0.00004396503,0.00007587574,0.0001437564,0.00005336569,0.0001413666,0.0001170201,0.0001528196,0.0002621203,0.0001194529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000236492,"about_ca_system_score_gemma":0.0001530316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008501104,"about_ca_topic_score_gemma":0.001460044,"domain_scores_codex":[0.9999377,0.000007511298,0.00000457171,0.00001784972,0.00001402502,0.00001842344],"domain_scores_gemma":[0.9999566,0.000004227576,0.00001777481,0.000004566746,0.000006192032,0.00001063813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004188421,0.000005608846,0.0001291924,0.00001201215,0.000001223777,0.00001668797,0.000006464638,0.00001442985,0.9994013,0.00002586302,0.0000071621,0.0003381138],"study_design_scores_gemma":[0.00001017822,0.0001936989,0.01381814,0.000005206546,0.00001214543,0.00009839897,0.0000428592,0.000814362,0.9835358,0.00004258341,0.001422253,0.000004432704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973184,0.0007879812,0.0008247257,0.00004989695,0.00001066148,0.00001287247,0.0001101848,0.00003531717,0.0008497805],"genre_scores_gemma":[0.9979268,0.0003350311,0.0005039017,0.00002258119,0.00000259894,0.000009404377,0.0001435786,0.000005785575,0.001050169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008501104,"threshold_uncertainty_score":0.001715899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588745024128724,"score_gpt":0.2679423295753282,"score_spread":0.2520548793340409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}