{"id":"W2551339155","doi":"10.1038/srep37601","title":"Regulation of Anticancer Styrylpyrone Biosynthesis in the Medicinal Mushroom Inonotus obliquus Requires Thioredoxin Mediated Transnitrosylation of S-nitrosoglutathione Reductase","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Fungal Biology and Applications","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Genetics; Institute of Microbiology, Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Biosynthesis; Reductase; Thioredoxin; Thioredoxin reductase; Biochemistry; Inonotus obliquus; Nitric oxide; Phenylpropanoid; Chemistry; Polyphenol; Enzyme; Cell biology; Biology; Antioxidant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002185128,0.0001183341,0.0003048186,0.0002834391,0.00009218998,0.000007833743,0.0001073508,0.0001263862,0.0002314868],"category_scores_gemma":[0.0005971265,0.000064756,0.00008285672,0.0008340658,0.0009885548,0.0001203276,0.00001531752,0.0001013467,0.000005263123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004372409,"about_ca_system_score_gemma":0.0002468708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006292568,"about_ca_topic_score_gemma":0.00005162149,"domain_scores_codex":[0.9978932,0.0001274262,0.0008364538,0.0004214977,0.0005219578,0.000199539],"domain_scores_gemma":[0.9982544,0.0002587179,0.0004858176,0.000697569,0.0002440762,0.00005942207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001219774,0.0001646457,0.02374645,0.00003683936,0.00001932112,0.00002206173,0.0006014101,0.000001948413,0.9701217,0.0004431426,0.0003821613,0.004338297],"study_design_scores_gemma":[0.0005883462,0.0001436459,0.311418,0.0002452383,0.00008559579,0.0001264934,0.0003582746,0.00002333086,0.6807637,0.005281749,0.0008742483,0.00009131753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931674,0.0002907541,0.0001966012,0.004939849,0.0004298062,0.0005525236,0.00002572122,0.0000220942,0.000375236],"genre_scores_gemma":[0.9992556,0.00003244703,0.0003581256,0.00004075612,0.00005488482,0.000035633,0.00009254129,0.000008494383,0.0001215306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.289358,"threshold_uncertainty_score":0.3642371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588745024128724,"score_gpt":0.2679423295753282,"score_spread":0.2520548793340409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}