{"id":"W2551484138","doi":"10.1071/ch16589","title":"Synthesis and Protein Engineering Applications of Cyclotides","year":2016,"lang":"en","type":"article","venue":"Australian Journal of Chemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Research (Canada)","funders":"Australian Research Council; Medical Research Council","keywords":"Chemistry; Native chemical ligation; Combinatorial chemistry; Biocatalysis; Protein engineering; Cyclic peptide; Residue (chemistry); Linker; Protein design; Chemical ligation; Chemical synthesis; Peptide; Folding (DSP implementation); Protein folding; Stereochemistry; Enzyme; Protein structure; Biochemistry; Catalysis; Reaction mechanism; In vitro; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005289811,0.00006753718,0.00009720523,0.0000104753,0.000009562537,0.000004930311,0.00009070188,0.00007834938,0.00002617939],"category_scores_gemma":[0.00009046692,0.00004573931,0.00004606241,0.00003038729,0.00005056843,0.000005071816,0.00001849499,0.00003911543,2.566589e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000454751,"about_ca_system_score_gemma":0.00001605282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.395205e-7,"about_ca_topic_score_gemma":2.691648e-8,"domain_scores_codex":[0.9995815,0.000004998019,0.0002015628,0.00007636662,0.00006200845,0.00007354838],"domain_scores_gemma":[0.9996111,0.000009420526,0.0001558729,0.00008405505,0.00007613382,0.00006338364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002029557,0.000007499355,0.0006708631,0.00006229358,0.00002294648,5.792444e-7,0.00000248789,6.132385e-7,0.9963276,0.000003553336,0.00005139533,0.002829834],"study_design_scores_gemma":[0.0001333893,0.0000218342,0.001642585,0.00008184263,0.00001203653,0.0000626789,0.000006025352,1.752984e-7,0.9961499,0.00004491404,0.001783102,0.00006154078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987844,0.00006616234,0.000763057,0.0002904791,0.00000933864,0.00003548437,0.00001393174,0.00000182268,0.00003528552],"genre_scores_gemma":[0.9985246,0.00003918698,0.0008458555,0.000003986604,0.0001480141,0.000004519735,0.000002643998,0.000006028379,0.0004251392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002768293,"threshold_uncertainty_score":0.1865195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004958261410912306,"score_gpt":0.2004792450367186,"score_spread":0.1955209836258063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}