{"id":"W2551484138","doi":"10.1071/ch16589","title":"Synthesis and Protein Engineering Applications of Cyclotides","year":2016,"lang":"en","type":"article","venue":"Australian Journal of Chemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Research (Canada)","funders":"Australian Research Council; Medical Research Council","keywords":"Chemistry; Native chemical ligation; Combinatorial chemistry; Biocatalysis; Protein engineering; Cyclic peptide; Residue (chemistry); Linker; Protein design; Chemical ligation; Chemical synthesis; Peptide; Folding (DSP implementation); Protein folding; Stereochemistry; Enzyme; Protein structure; Biochemistry; Catalysis; Reaction mechanism; In vitro; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289911,0.0004145052,0.0002971168,0.0004174334,0.0002382085,0.000491559,0.000246608,0.000447672,0.001634442],"category_scores_gemma":[0.0002601438,0.0002107715,0.0004443973,0.000487571,0.0002349568,0.0004736678,0.0004134905,0.0008822128,0.001416872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003770516,"about_ca_system_score_gemma":0.0002178333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001703943,"about_ca_topic_score_gemma":0.0002904997,"domain_scores_codex":[0.9998192,0.00002355749,0.00001885716,0.0000533134,0.00005475668,0.00003037863],"domain_scores_gemma":[0.9999207,0.00001333147,0.00001903703,0.00001236752,0.0000188626,0.00001561279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005918315,0.00004286835,0.0001183188,0.0006425162,0.00001299955,0.0002641812,0.00008190777,0.000661251,0.9700528,0.003276889,0.0005421712,0.02424492],"study_design_scores_gemma":[0.00001643531,0.0003654111,0.0007124984,0.00009973752,0.00002559362,0.0009604053,0.00004549022,0.00103423,0.8778604,0.0009468809,0.1179089,0.0000240983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5894781,0.1100513,0.2056008,0.001902024,0.001394662,0.0006407907,0.003099291,0.001211435,0.08662163],"genre_scores_gemma":[0.8001402,0.07231578,0.1021573,0.0005016198,0.0001526639,0.0003504193,0.002926309,0.0002329232,0.02122272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634442,"threshold_uncertainty_score":0.005467772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004958261410912306,"score_gpt":0.2004792450367186,"score_spread":0.1955209836258063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}